GUCA1A Antibodies

AND GUCA1A ELISA kits, GUCA1A Proteins

Many biological assays use antibodies to detect GUCA1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GUCA1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GUCA1A antibodies...

We validate the specificity of these antibodies to GUCA1A by testing them on tissues known to express GUCA1A positively and negatively. Browse below to find the GUCA1A antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GUCA1A Infographic by Boster Bio

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GCAP1 (GUCA1A) (NM_000409) Human Recombinant Protein

$1062
Cat # PROTP43080
20 µg

GUCA1A Overview

Facts about Guanylyl cyclase-activating protein 1.

GUCA1A 3D structure. Source: alphafold

Guanylyl cyclase-activating protein 1 (GUCA1A)

Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is raised (PubMed:19459154). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is an integral event in retrieval of the dark state of rod photoreceptors following light exposure.

Gene Information

Human
Gene Name:	GUCA1A
Uniprot:	P43080
Entrez:	2978

Family

Belongs to:

No superfamily

Alternative Names

C6orf131; chromosome 6 open reading frame 131; CORD14; GCAP 1; GCAP1photoreceptor 1; GCAPGUCA; guanylate cyclase activator 1A (retina); Guanylate cyclase activator 1A; guanylin 1, retina; guanylyl cyclase-activating protein 1; GUCA1

Molecular Weight

Mass (kDA):
22.92 kDA

Genomic Context


Human

Location:	6p21.1
Sequence:	6; NC_000006.12 (42155406..42180056)

Tissue Specificity

Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.

Subcellular Localizations

Membrane; Lipid-anchor. Cell projection, cilium, photoreceptor outer segment. Subcellular location is not affected by light or dark conditions.

Diseases

Dystrophy
Retinitis Pigmentosa
Retinal Degeneration
Retinal Diseases
Amaurosis
Leber Congenital Amaurosis
Retinal Dystrophies
Color Vision Defect
Age Related Macular Degeneration
Photophobia

Atrophy
Abnormal Degeneration
Blind Vision
Optic Atrophies, Hereditary
Disorder Of Eye

Pathways

Phototransduction
Localization
Pathogenesis
Proteolysis
Lipid Modification
Response To Light Stimulus
Translation
Gene Silencing
Cell Death

Fertilization
Rna Interference
Apoptotic Process

PTMs

Myristoylation
Phosphorylation

Dephosphorylation
Acylation

Research Areas

Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GUCA1A

References

PMID: 7983048 by Subbaraya I., et al. Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene.

PMID: 9425234 by Payne A.M., et al. A mutation in guanylate cyclase activator 1A (GUCA1A) in an autosomal dominant cone dystrophy pedigree mapping to a new locus on chromosome 6p21.1.