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- Table of Contents
, No Gclids
Progranulin Antibodies
AND GRN ELISA kits, Progranulin Proteins
Many biological assays use antibodies to detect Progranulin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Progranulin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Progranulin antibodies...
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GRN Infographic by Boster Bio
All GRN Products
Product
Figures
Specificity
Applications
Price
Human Progranulin ELISA Kit PicoKine®
2 Citations 8 Q&As
Human
ELISA
$499
Cat # EK0973
96 wells/kit, with removable strips.
Cat # EK0973
96 wells/kit, with removable strips.
Mouse Progranulin ELISA Kit PicoKine®
1 Citations 9 Q&As
Mouse
ELISA
$499
Cat # EK1192
96 wells/kit, with removable strips.
Cat # EK1192
96 wells/kit, with removable strips.
Mouse
ELISA
$499
Cat # FEK1192
96 wells/kit, with removable strips.
Cat # FEK1192
96 wells/kit, with removable strips.
Human
IHC, WB
$523
Cat # M00893
100 µl
Cat # M00893
100 µl
GRN Overview
Facts about Progranulin.
Progranulin (GRN)
Granulins have potential cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.
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Gene Information
| Human | |
|---|---|
| Gene Name: | GRN |
| Uniprot: | P28799 |
| Entrez: | 2896 |
Family
| Belongs to: |
|---|
| granulin family |
Alternative Names
Acrogranin; CLN11; GEP; GP88; granulin precursor; GRN; PCDGF; PEPI; PGRN; Proepithelin; Progranulin
Molecular Weight
Mass (kDA):
63.544 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.31 |
| Sequence: | 17; NC_000017.11 (44345302..44353106) |
Tissue Specificity
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Subcellular Localizations
Secreted. Lysosome. Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity).
Diseases
- Dementia
- Frontotemporal Lobar Degeneration
- Frontotemporal Dementia
- Neurodegenerative Disorders
- Alzheimer's Disease
- Malignant Neoplasms
- Nerve Degeneration
- Aphasia
- Haploinsufficiency
- Neoplasms
- Sclerosis
- Inflammation
- Atrophy
Interacting Proteins
- ARFGAP1
- CACNA1A
- DBN1
- DLX2
- FANCL
- GLRX3
- HOXA1
- Hoxa1
- KRTAP10-7
- KRTAP26-1
Pathways
- Pathogenesis
- Cell Cycle
- Cell Growth
- Localization
- Secretion
- Cell Proliferation
- Cell Differentiation
- Gastrulation
- Angiogenesis
- Cell Migration
- Neurogenesis
- Inflammatory Response
- Wound Healing
PTMs
- Ubiquitination
- Phosphorylation
- Cleavage
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GRN
bosterbio.com/bosterbio-gene-info-cards/GRN
References
PMID: 1417868 by Bhandari V., et al. Structure and chromosomal location of the human granulin gene.
PMID: 1618805 by Plowman G.D., et al. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
2 Publications of Boster Progranulin Antibodies & ELISA Kits
- PubMed ID: 10.1158/0008-5472.CAN-20-0912, A GRN Autocrine-dependent FAM135B/AKT/mTOR Feedforward Loop Promotes Esophageal ...
- PubMed ID: 33635854, Zhou T,Chen Y,Zhang S,Li M,Wang J.Serum Progranulin As a Risk Predictor in Patie...
*More publications can be found for each product on its corresponding product page