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- Table of Contents
Facts about G-protein coupled receptor 26.
Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, leading to an elevation of intracellular cAMP. .
Human | |
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Gene Name: | GPR26 |
Uniprot: | Q8NDV2 |
Entrez: | 2849 |
Belongs to: |
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G-protein coupled receptor 1 family |
DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; GPR26; G-protein coupled receptor 26; MGC138216
Mass (kDA):
37.604 kDA
Human | |
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Location: | 10q26.13 |
Sequence: | 10; NC_000010.11 (123666355..123697399) |
Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.
Cell membrane; Multi-pass membrane protein.
PMID: 17363172 by Jones P.G., et al. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78.
PMID: 18037267 by Carter A.N., et al. GPR26: a marker for primary glioblastoma?