GPR161 Antibodies

AND GPR161 ELISA kits, GPR161 Proteins

Many biological assays use antibodies to detect GPR161, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR161 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR161 antibodies...

We validate the specificity of these antibodies to GPR161 by testing them on tissues known to express GPR161 positively and negatively. Browse below to find the GPR161 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR161 Infographic by Boster Bio

All GPR161 Products

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Product

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Specificity

Applications

Price

Anti-GP161 GPR161 Antibody

Human

ELISA, WB

$380
Cat # A10567
100ul

Anti-GPR161 Antibody Picoband®

Human, Mouse, Rat

$370
Cat # A10567-1
100 μg/vial

GPR161 (NM_153832) Human Over-expression Lysate

Human

$628
Cat # LS023432
100 µg

GPR161 Overview

Facts about G-protein coupled receptor 161.

GPR161 3D structure. Source: alphafold

G-protein coupled receptor 161 (GPR161)

Key negative regulator of Shh signaling, which promotes the processing of GLI3 to GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complicated to primary cilia and functions as a regulator of the PKA-dependent basal repression machines in Shh signaling by increasing cAMP levels, contributing to promote the PKA-dependent processing of GLI3 to GLI3R and repress the Shh signaling.

In presence of SHH, it's eliminated from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).

Gene Information

Human
Gene Name:	GPR161
Uniprot:	Q8N6U8
Entrez:	23432

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

FLJ33952; G protein-coupled receptor 161; Gm208; GPR161; G-protein coupled receptor 161; G-protein coupled receptor RE2; RE2

Molecular Weight

Mass (kDA):
58.559 kDA

Genomic Context


Human

Location:	1q24.2
Sequence:	1; NC_000001.11 (168079542..168137667, complement)

Subcellular Localizations

Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity).

Diseases

Cataract

Pathways

Receptor-mediated Endocytosis
Endocytosis

PTMs

Disulfide bond

Glycoprotein

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPR161

References

PMID: 9932290 by Raming K., et al. Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone.