GPR143 Antibodies

AND GPR143 ELISA kits, GPR143 Proteins

Many biological assays use antibodies to detect GPR143, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GPR143 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GPR143 antibodies...

We validate the specificity of these antibodies to GPR143 by testing them on tissues known to express GPR143 positively and negatively. Browse below to find the GPR143 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPR143 Infographic by Boster Bio

All GPR143 Products

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Specificity

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Anti-GPR143/Oa1 Antibody

1 Q&As

Human, Mouse

ELISA, IF, ICC

$335
Cat # A30809
100ul

Anti-G-protein coupled receptor 143 GPR143 Antibody

Human, Mouse, Rat

$405
Cat # A02921
100ul

GPR143 Overview

Facts about G-protein coupled receptor 143.

GPR143 3D structure. Source: alphafold

G-protein coupled receptor 143 (GPR143)

Receptor for tyrosine, L-DOPA and dopamine.
After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin in the plasma membrane; this ligand- dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells.

Its action is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Gene Information

Human
Gene Name:	GPR143
Uniprot:	P51810
Entrez:	4935

Family

Belongs to:

G-protein coupled receptor OA family

Alternative Names

G protein-coupled receptor 143; G-protein coupled receptor 143; NYS6; OA1Ocular albinism type 1 protein; ocular albinism 1 (Nettleship-Falls)

Molecular Weight

Mass (kDA):
43.878 kDA

Genomic Context


Human

Location:	Xp22.2
Sequence:	X; NC_000023.11 (9725346..9786260, complement)

Tissue Specificity

Expressed at high levels in the retina, including the retinal pigment epithelium (RPE), and in melanocytes. Weak expression is observed in brain and adrenal gland.

Subcellular Localizations

Melanosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673).