Gephyrin Antibodies

AND GPHN ELISA kits, Gephyrin Proteins

Many biological assays use antibodies to detect Gephyrin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Gephyrin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Gephyrin antibodies...

We validate the specificity of these antibodies to Gephyrin by testing them on tissues known to express GPHN positively and negatively. Browse below to find the GPHN antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GPHN Infographic by Boster Bio

All GPHN Products

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Specificity

Applications

Price

Anti-Gephyrin GPHN Antibody

Human, Mouse, Rat

$405
Cat # A04560
100ul

Anti-Gephyrin (GPHN) Mouse Monoclonal Antibody [Clone ID: OTI2C2]

Human, Mouse, Rat

Flow Cytometry, IF, WB

$523
Cat # M04560-1
100 µl

Anti-Gephyrin (GPHN) Mouse Monoclonal Antibody [Clone ID: OTI3A6]

Human, Monkey, Mouse, Rat

Flow Cytometry, WB

$523
Cat # M04560-2
100 µl

Anti-Gephyrin (GPHN) Mouse Monoclonal Antibody [Clone ID: OTI3C6]

Human, Mouse, Rat

Flow Cytometry, IHC, WB

$523
Cat # M04560
100 µl

Anti-Gephyrin/GPHN Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A04560-1
100 μg/vial

Anti-Gephyrin Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, IHC, ICC, WB

$370
Cat # M04560-3
100 μl/vial

Gephyrin (GPHN) (NM_020806) Human Over-expression Lysate

Human

$628
Cat # LS010243
100 µg

GPHN Overview

Facts about Gephyrin.

GPHN 3D structure. Source: alphafold

Gephyrin (GPHN)

Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It's supposed to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules.

Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated.

Gene Information

Human
Gene Name:	GPHN
Uniprot:	Q9NQX3
Entrez:	10243

Family

Belongs to:

No superfamily

Alternative Names

GEPH; Gephyrin; GPH; GPHN; GPHRYN; KIAA1385GPHGEPH

Molecular Weight

Mass (kDA):
79.748 kDA

Genomic Context


Human

Location:	14q23.3-q24.1
Sequence:	14; NC_000014.9 (66507934..67181805)

Subcellular Localizations

Cell junction, synapse. Cell junction, synapse, postsynaptic cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, dendrite. Cell junction, synapse, postsynaptic density. Cytoplasmic face of glycinergic postsynaptic membranes.

Diseases

Hyperexplexia
Muscle Hypertonia
Combined Molybdoflavoprotein Enzyme Deficiency
Nervous System Disorder
Leukemia
Mutation, Out-of-frame
Apnea
Chromosomal Translocation
Paraplegia
Leukemogenesis
Spastic Paraplegia

Neoplasms, Experimental
Trauma, Nervous System
Dyskinetic Syndrome
Myeloid Leukemia
Dyskinesia, Drug-induced
Chromosome Breakage

Interacting Proteins

DYNLL1

Pathways

Startle Response
Localization
Chromosome Localization
Error-prone Dna Repair
Dna Repair
Synaptic Transmission

Reflex

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPHN

References

PMID: 10839351 by Butler M.H., et al. Autoimmunity to gephyrin in Stiff-Man syndrome.

PMID: 11095995 by Reiss J., et al. A mutation in the gene for the neurotransmitter receptor-clustering protein gephyrin causes a novel form of molybdenum cofactor deficiency.