GPD1L Antibodies

Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L)

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, can ultimately lead to decreased sodium current; cardiac sodium current may also be reduced because of alterations of NAD(H) balance induced by DPD1L. .

Gene Information

Human
Gene Name:	GPD1L
Uniprot:	Q8N335
Entrez:	23171

Family

Belongs to:
NAD-dependent glycerol-3-phosphate dehydrogenase family

Alternative Names

EC 1.1.1; EC 1.1.1.8; glycerol-3-phosphate dehydrogenase 1-like protein; glycerol-3-phosphate dehydrogenase 1-like; KIAA0089GPD1-L

Molecular Weight

Mass (kDA):
38.419 kDA

Genomic Context

Human
Location:	3p22.3
Sequence:	3; NC_000003.12 (32106620..32168715)

Tissue Specificity

Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.

Subcellular Localizations

Cytoplasm. Localized to the region of the plasma membrane.

Diseases

• Cardiac Arrhythmia
• Brugada Syndrome (disorder)
• Hypoxia
• Sudden Death
• Sudden Cardiac Death
• Long Qt Syndrome
• Cardiac Fibrillation
• Cardiac Death
• Cystic Fibrosis
• Myocardial Ischemia
• Sudden Infant Death Syndrome
• Coronary Artery Disease

• Fibrosis
• Neoplasms
• Cardiac Arrest
• Anoxia
• Sudden Cardiac Arrest
• Ventricular Fibrillation
• Ischemia

Pathways

• Endothelial Cell Migration
• Cell Migration
• Cell Cycle
• Response To Hypoxia
• Rna Processing

PTMs

• Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GPD1L

Best Uses Of The GPD1L Marker From Boster Bio

Boster Bio stocks a High-affinity primary anti-GPD1L antibody. These antibodies have been validated for use in Western Blotting, Immunohistochemistry, and ELISA. Boster antibodies are cited in scientific literature so you can be sure that your research will be reproducible.

Primary antibodies of high affinity

Immunoprecipitation was performed using U2OS cells grown in a 384-well cell carrier plate. The cells were fixed using 3.7% formaldehyde, and permeated with 0.1% Triton X100 in 1x PBS. The cells were then hybridized using fluorescent probes with far-red dyes, and counterstained using Hoechst 33422. Cells were visualized using a Leica DMILED FLUO microscope.

GPD1L indicator

Commonly, biological assays can be used to detect Vasculin-1-like protein. Boster Bio has created monoclonal antibodies that react to this protein. These antibodies react to Vasculin-like Protein 1 in a number animal samples. Boster Bio created antibodies against this protein using rabbits and mice as models. Their antibodies are highly specific and are widely used in research.