GOT2 Antibodies

Aspartate aminotransferase, mitochondrial (GOT2)

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a crucial role in amino acid metabolism.

Significant for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.

Gene Information

Human
Gene Name:	GOT2
Uniprot:	P00505
Entrez:	2806

Family

Belongs to:
class-I pyridoxal-phosphate-dependent aminotransferase family

Alternative Names

aspartate aminotransferase, mitochondrial; EC 2.6.1; EC 2.6.1.1; FABP-1; FABPpm; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase2); KAT4; KATIV; kynurenine aminotransferase IV; mAspAT; mitAAT; Plasma membrane-associated fatty acid-binding protein; Transaminase A

Molecular Weight

Mass (kDA):
47.518 kDA

Genomic Context

Human
Location:	16q21
Sequence:	16; NC_000016.10 (58707131..58734316, complement)

Subcellular Localizations

Mitochondrion matrix. Cell membrane. Exposure to alcohol promotes translocation to the cell membrane.

Diseases

• Carcinoma
• Neoplasms
• Medullary Carcinoma Of Thyroid
• Malignant Neoplasm Of Thyroid
• Hyperplastic Polyp
• Thyroid Neoplasm
• Kidney Neoplasm
• Sarcoma
• Carcinoid Tumor
• Osteoporosis
• Fatty Liver
• Bladder Neoplasm

• Cell Transformation, Neoplastic
• Bisphosphonate-associated Osteonecrosis
• Steatohepatitis
• Schizophrenia
• Tissue Adhesions
• Steatosis

Pathways

• Localization
• Chromosome Localization
• Cell Adhesion
• Pathogenesis

PTMs

• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GOT2

Best Uses Of The GOT2 Marker

The GOT2 marker is a human protein expressed from E. coli. Its 30-430aa sequence area is used for SDS/PAGE. GOT2 markers can be stored at 2degC - 8degC for up one week. It can also be stored at -20degC to -80degC but avoid repeated freeze-thaw cycles. The GOT2 marker can be used by all scientists worldwide.

Steven Boster

Steven Boster was a San Angelo native. After practicing emergency medicine 33 years, he switched to full time painting. Boster's style varies from early impressionism through realism. He also uses vivid colors. He was an avid hunter and outdoor enthusiast for his entire life. Many of his works were donated by him to the Fisher House Foundation, which provides meals for veterans in hospitals.