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- Table of Contents
Facts about Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2.
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Mouse | |
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Gene Name: | Gng2 |
Uniprot: | P63213 |
Entrez: | 14702 |
Belongs to: |
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G protein gamma family |
G gamma-I; guanine nucleotide binding protein (G protein), gamma 2; guanine nucleotide binding protein gamma 2; guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Mass (kDA):
7.85 kDA
Mouse | |
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Location: | 14 A3|14 11.17 cM |
Sequence: | 14; |
Adrenal gland and brain.
Boster Bio Anti GNG2 marker is worth considering for many reasons. This article will cover the cost, safety, and application of this marker. This article will discuss the advantages of the GNG2 markers for tissue from mice and rats. Read on to learn more! Below are the most popular uses of the GNG2 marker in mouse and rat tissue. Listed below are the three most common applications of this GNG2 marker.
Before being sold to the scientific community, the Boster Bio Anti–GNG2 Markers have been tested on a variety of animal models. These antibodies are produced by immunizing rabbits infected with synthetic peptides. They have a proven history of reliability and have been validated against known positive and negative samples. Boster Bio Anti–GNG2 marker can be used for WB analysis. These antibodies have been shown to detect human, mouse, and rat GNG2 and other signaling proteins in cell culture.
GNG2 may be inhibited with a mononucleotide which is directed against the GNG2 genetic gene. This recombinant molecule may be combined with a regulatory sequence in order to control constitutive or continuous expressions of antisenseRNA. This recombinant molecule might inhibit the expression VEGF or GNG2.
This gene is found in many foetuses, including the testis of mice. It is a molecular target for BC. Researchers can identify the protein's expression level and develop a therapeutic strategy by targeting it. GNG2 may be a new molecular target for malignant skin cancer treatment. Its biological significance is still unknown. This marker is a useful tool in a number of studies.
Akt regulates the expression of GNG2 within BC cells. It regulates cell proliferation and inhibits ERK activity. It also inhibits ERK activity and regulates glycogen mobilization. Because GNG2 interferes with ERK and Akt activity, disruption of this protein could be a promising therapeutic approach for BC. GNG2's gene has a lot of functional overlap regions that have a wide range biological functions. It is also involved with tumor cell growth, cancer metastasis and inflammation.
GSK3b activity regulation is another application of the GNG2 genes. More experiments are needed to validate GNG2 in the context of glycogen storage or mitochondrial function. The GNG2 marker is an important marker for gene transcription analysis. Its exact role and applications in different fields require further research. Understanding how GNG2 impacts glycogen storage is crucial.
Expression of GNG2 in the blood was studied in clinical samples in the TCGA database. Lower levels of the gene were associated with poorer survival in the luminal A, HER2, and TNBC subtypes. In the multivariate Cox regression analysis, GNG2 expression was independently associated with poor prognosis in the BC subtypes. These results suggest that GNG2 is a potential marker of disease progression and treatment response.
The safety of GNG2 as a clinical marker in melanoma patients is unknown, despite the fact it is expressed in malignant tissues. GNG2 protein levels are found to inhibit malignant melanoma cells proliferation and metastasis. This gene could be a biomarker for this condition. The protein mediates Akt signaling and nuclear factor-kB activation. This biomarker has been associated with clinical responses and measures of thiopurine metabolite.
GNG2 genes are essential components of the cytoskeleton. The increased expression of this gene in malignant melanoma cell growth inhibits them in vitro as well as in vivo. This protein could be a novel target for malignant melanomas therapy. But how much is this gene worth? What is its potential function? Let's take a closer look at this question.
PMID: 10191100 by Downes G.B., et al. Chromosomal mapping of five mouse G protein gamma subunits.
PMID: 8858601 by Williams C.J., et al. G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development.