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GNAI1 Antibodies
AND GNAI1 ELISA kits, GNAI1 Proteins
Many biological assays use antibodies to detect GNAI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GNAI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GNAI1 antibodies...
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GNAI1 Infographic by Boster Bio
All GNAI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
WB
$523
Cat # M03034
100 µl
Cat # M03034
100 µl
Human
$628
Cat # LS002770
100 µg
Cat # LS002770
100 µg
GNAI1 Overview
Facts about Guanine nucleotide-binding protein G(i) subunit alpha-1.
Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and contrasts between an energetic, GTP-bound state and an inactive, GDP-bound state.
Signaling by an activated GPCR boosts GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the sign.
Gene Information
| Human | |
|---|---|
| Gene Name: | GNAI1 |
| Uniprot: | P63096 |
| Entrez: | 2770 |
Family
| Belongs to: |
|---|
| G-alpha family |
Alternative Names
Adenylate cyclase-inhibiting G alpha protein; Gi; Gi1 protein alpha subunit; guanine nucleotide binding protein (G protein), alpha inhibiting activitypolypeptide 1; guanine nucleotide-binding protein G(i) subunit alpha-1
Molecular Weight
Mass (kDA):
40.361 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q21.11 |
| Sequence: | 7; NC_000007.14 (80134831..80226181) |
Subcellular Localizations
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cell cortex. Membrane; Lipid-anchor. Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody (PubMed:17635935). Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane.
Diseases
- Malignant Neoplasms
- Neoplasms
- Pertussis
- Adenocarcinoma
- Solid Tumor
- Heart Failure
- Colonic Neoplasms
- Malignant Tumor Of Colon
- Schizophrenia
- Hypoxia
- Tissue Adhesions
- Diphtheria
Interacting Proteins
- CNR1
- DRD2
- GPSM2
- GPSM3
- NUMA1
- RGS17
Pathways
- Localization
- Vascular Smooth Muscle Contraction
- Drug Resistance
- Smooth Muscle Contraction
- Cell Cycle
- Cell Development
PTMs
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GNAI1
bosterbio.com/bosterbio-gene-info-cards/GNAI1
References
PMID: 2834384 by Itoh H., et al. Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.
PMID: 3110783 by Bray P., et al. Human cDNA clones for an alpha subunit of Gi signal-transduction protein.