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- Table of Contents
Facts about Guanine nucleotide-binding protein subunit alpha-12.
GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452).
Human | |
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Gene Name: | GNA12 |
Uniprot: | Q03113 |
Entrez: | 2768 |
Belongs to: |
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G-alpha family |
G alpha-12; gep; G-protein subunit alpha-12; guanine nucleotide binding protein (G protein) alpha 12; guanine nucleotide-binding protein subunit alpha-12; MGC104623; MGC99644; NNX3; RMP; WUGSC:H_GS165O14.2
Mass (kDA):
44.279 kDA
Human | |
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Location: | 7p22.3-p22.2 |
Sequence: | 7; NC_000007.14 (2728105..2844308, complement) |
Cell membrane; Lipid-anchor. Lateral cell membrane; Lipid-anchor. Cytoplasm. CDH1 enhances cell membrane localization.
PMID: 8423800 by Chan A.M.-L., et al. Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
PMID: 10026210 by Fukuhara S., et al. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho.