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- Table of Contents
Facts about Glutaminase liver isoform, mitochondrial.
Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.
Human | |
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Gene Name: | GLS2 |
Uniprot: | Q9UI32 |
Entrez: | 27165 |
Belongs to: |
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glutaminase family |
EC 3.5.1.2; GAbreast cell glutaminase; GLSglutaminase GA; glutaminase 2 (liver, mitochondrial); glutaminase I; glutaminase liver isoform, mitochondrial; hLGA; LGA; L-glutaminase; L-glutamine amidohydrolase; MGC71567; phosphate-activated glutaminase; phosphate-dependent glutaminase; truncated glutaminase 2
Mass (kDA):
66.323 kDA
Human | |
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Location: | 12q13.3 |
Sequence: | 12; NC_000012.12 (56470944..56488414, complement) |
Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.
Mitochondrion.
PMID: 10620514 by Gomez-Fabre P.M., et al. Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.
PMID: 12444921 by Perez-Gomez C., et al. Genomic organization and transcriptional analysis of the human l- glutaminase gene.