This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
GLRB Antibodies
AND GLRB ELISA kits, GLRB Proteins
Many biological assays use antibodies to detect GLRB, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GLRB in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GLRB antibodies...
Previous: CBLIF
Next: GLUD1
GLRB Infographic by Boster Bio
All GLRB Products
Product
Figures
Specificity
Applications
Price
GLRB Overview
Facts about Glycine receptor subunit beta.
Glycine receptor subunit beta (GLRB)
Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is a part of heteromeric ligand-gated chloride channels.
Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric stations composed of GLRB and GLRA1 are triggered by reduced glycine levels than homopentameric GLRA1 (PubMed:8717357).
Gene Information
| Human | |
|---|---|
| Gene Name: | GLRB |
| Uniprot: | P48167 |
| Entrez: | 2743 |
Family
| Belongs to: |
|---|
| ligand-gated ion channel (TC 1.A.9) family |
Alternative Names
beta subunit; Glycine receptor 58 kDa subunit; glycine receptor, beta
Molecular Weight
Mass (kDA):
56.122 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4q32.1 |
| Sequence: | 4; NC_000004.12 (157076125..157172090) |
Subcellular Localizations
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Cytoplasm. Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523). Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane.
Diseases
- Hyperexplexia
- Muscle Hypertonia
- Nervousness
- Nervous System Disorder
- Apnea
- Epilepsy
- Muscular Stiffness
- Muscle Spasticity
- Mutation, Out-of-frame
- Sudden Infant Death Syndrome
- Pain
Pathways
- Startle Response
- Reflex
- Synaptic Transmission
- Localization
- Transport
- Signal Transmission
- Receptor Clustering
- Acrosome Reaction
- Gephyrin Clustering
- Cell Proliferation
- Glycine Transport
PTMs
- Hydroxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLRB
bosterbio.com/bosterbio-gene-info-cards/GLRB
References
PMID: 8717357 by Handford C.A., et al. The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
PMID: 9676428 by Milani N., et al. The human glycine receptor beta subunit gene (GLRB): structure, refined chromosomal localization, and population polymorphism.