GLRA1 Antibodies

AND GLRA1 ELISA kits, GLRA1 Proteins

Many biological assays use antibodies to detect GLRA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GLRA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GLRA1 antibodies...

We validate the specificity of these antibodies to GLRA1 by testing them on tissues known to express GLRA1 positively and negatively. Browse below to find the GLRA1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GLRA1 Infographic by Boster Bio

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alpha 1 Glycine Receptor (GLRA1) (NM_000171) Human Over-expression Lysate

Human

$628
Cat # LS002741
100 µg

GLRA1 Overview

Facts about Glycine receptor subunit alpha-1.

GLRA1 3D structure. Source: alphafold

Glycine receptor subunit alpha-1 (GLRA1)

Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272).

Channel characteristics are determined by the subunit composition; heteropentameric stations are activated by reduced glycine levels and exhibit faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272).

Gene Information

Human
Gene Name:	GLRA1
Uniprot:	P23415
Entrez:	2741

Family

Belongs to:

ligand-gated ion channel (TC 1.A.9) family

Alternative Names

GLRA 1; GLRA1; Glycine receptor 48 kDa subunit; Glycine receptor strychnine-binding subunit; glycine receptor subunit alpha-1; glycine receptor, alpha 1 (startle disease/hyperekplexia); glycine receptor, alpha 1; HKPX1; MGC138878; MGC138879; STHE

Molecular Weight

Mass (kDA):
52.624 kDA

Genomic Context


Human

Location:	5q33.1
Sequence:	5; NC_000005.10 (151822513..151924851, complement)

Subcellular Localizations

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Perikaryon. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein.

Diseases

Hyperexplexia
Muscle Hypertonia
Nervous System Disorder
Reflex, Abnormal
Stiff-person Syndrome
Apnea
Epilepsy
Muscle Rigidity
Nervousness
Congenital Stiff Person Syndrome
Myoclonus

Sudden Infant Death Syndrome
Muscular Stiffness
Protein Truncation Abnormality
Muscle Spasticity
Spasm

Pathways

Startle Response
Reflex
Localization
Transport
Glycine Transport
Secretory Pathway
Cellular Homeostasis
Receptor Clustering
Fertilization
Synaptic Transmission
Myelination

System Development
Acrosome Reaction
Cell Death
Nervous System Development
Pathogenesis

PTMs

Disulfide bond

Glycoprotein

Research Areas

Diabetes Research
Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLRA1

References

PMID: 2155780 by Grenningloh G., et al. Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes.

PMID: 7920629 by Ryan S.G., et al. A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse.