Glomulin Antibodies

AND GLMN ELISA kits, Glomulin Proteins

Many biological assays use antibodies to detect Glomulin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glomulin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glomulin antibodies...

We validate the specificity of these antibodies to Glomulin by testing them on tissues known to express GLMN positively and negatively. Browse below to find the GLMN antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GLMN Infographic by Boster Bio

All GLMN Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-Glomulin GLMN Antibody

Human, Mouse

$405
Cat # A07319
100ul

GLMN (NM_053274) Human Recombinant Protein

$813
Cat # PROTQ92990
20 µg

GLMN (NM_053274) Human Over-expression Lysate

Human

$628
Cat # LS011146
100 µg

Anti-GLMN Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A07319-1
100 μg/vial

GLMN Overview

Facts about Glomulin.

GLMN 3D structure. Source: alphafold

Glomulin (GLMN)

Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes (PubMed:22405651, PubMed:22748924). Inhibits E3 ubiquitin ligase activity by binding to RBX1 (through RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34 (PubMed:22405651, PubMed:22748924).

Inhibits RBX1-mediated neddylation of CUL1 (PubMed:22405651). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thus contributes to the regulation of CCNE1 and MYC levels (By similarity).

Gene Information

Human
Gene Name:	GLMN
Uniprot:	Q92990
Entrez:	11146

Family

Belongs to:

No superfamily

Alternative Names

FAP; FAP48FAP68; FKBPAP; GLMLFK506-binding protein-associated protein; glomulin; glomulin, FKBP associated protein; GVM; GVMFKBP-associated protein; VMGLOMvenous malformation with glomus cells

Molecular Weight

Mass (kDA):
68.208 kDA

Genomic Context


Human

Location:	1p22.1
Sequence:	1; NC_000001.11 (92245786..92441936, complement)

Tissue Specificity

Ubiquitous.

Diseases

Glomus Tumor
Glomuvenous Malformations
Skin Neoplasms
Extra-adrenal Paraganglioma
Vascular Anomaly
Congenital Vascular Anomaly
Neoplasms
Vascular Diseases
Arteriovenous Malformation
Pain
Pathologic Neovascularization
Germline Mutation Abnormality

Neoplastic Syndromes, Hereditary
Glomangioma
Neoplasm Metastasis
Varicosity
Hemangioma
Tumor Angiogenesis
Malignant Neoplasms

Interacting Proteins

FKBP4
RBX1

Pathways

Cell Activation
Muscle Cell Differentiation
T Cell Activation
Cell Differentiation
Angiogenesis
Pathogenesis
Vasculogenesis

Smooth Muscle Cell Differentiation
Viral Replication

PTMs

Phosphorylation

Ubiquitination

Dephosphorylation

Research Areas

Angiogenesis

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GLMN

References

PMID: 8955134 by Chambraud B., et al. FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin.

PMID: 11571281 by Grisendi S., et al. Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor.