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- Table of Contents
Facts about Gap junction delta-2 protein.
Mouse | |
---|---|
Gene Name: | Gjd2 |
Uniprot: | O54851 |
Entrez: | 14617 |
Belongs to: |
---|
connexin family |
Connexin 36; Connexin-36; CX36; CX36connexin 36; Gap junction alpha-9 protein; gap junction delta-2 protein; gap junction protein, alpha 9, 36kDa; gap junction protein, delta 2, 36kDa; GJA9connexin-36; GJD2; MGC138315; MGC138319
Mass (kDA):
36.082 kDA
Mouse | |
---|---|
Location: | 2|2 E4 |
Sequence: | 2; |
Highly expressed in neurons.
When you purchase antibodies or ELISA kits from Boster Bio, you can be confident that they will meet the specifications listed on the data sheet. These products are derived from pooled populations of immunoglobulins from the target species. Your research will be a success if you use the right Boster antigen. Here are a few tips for choosing an antibody.
Boster bio GJD2 antibodies and immunoassays are 100% reagents-grade and meet strict quality requirements. These reagents may be used only for research purposes and are not intended for diagnosis. Boster Bio GJD2 antibodies and ELISA kits are designed to detect a wide range of targets in a variety of samples.
ELISA allows you to determine the presence or absence protein in a sample. The concentration of the sample is compared to a standard or blank curve. The concentration of target proteins in the sample is directly proportional with the signal intensity produced by ELISA. In contrast, the ELISA kit produced by Boster is guaranteed to meet the specifications listed on the data sheet.
Although a limited number are currently able to detect this type, this is changing. Boster Bio GJD2 markers were made from immunoglobulins derived from the target species. These antibodies can also be used in diagnostic tests such as tumor markers. These antibodies have been described in several publications.
The most common antibodies used for this test in America are derived from American Indians (Chinese Americans), Chinese Americans (Chinese Americans), and Chinese. Boster Bio GJD2 markers were created by American Indians, Chinese Americans, Chinese scientists. Their findings are currently being published in a wide range of scientific journals. The company plans on commercializing its antibodies to detect infections.
These antibodies are highly specific for their target species. After immunizing a host animals with pooled immuneglobulins populations, the antiserum will be purified through immunoaffinitychromatography. This removes the host's serum proteins and minimizes cross reactivity in tissue and cell preps. Secondary antibodies are then attached to a variety if labels, including fluorescent dyes as well as enzymes.
The GJD2 protein is expressed in interneurons, which are part of the brain and are largely responsible for neural function. Mice with knockout GjD2 gene exhibit severe deficiency of electrical synapses within the neocortex. Therefore, the gene is crucial in gap junction formation.
Trypanosomes are a significant constraint on livestock production in sub Saharan Africa. However, there is a variety of genetically more resistant cattle breeds. This was proven by measuring B cells activation in six N'Dama and five Boran susceptible cattle, before they were subjected to Trypanosoma kongolense primary challenge. They also secrete more IgM which targets trypanosome deriv proteins such as ovalbumin or trypanosome deriv proteins.
The gene that controls the production of these antibodies is inserted into an intron of the eukaryotic genome, which is a copy of the original eukaryotic DNA. The genome inserts were created from pools immunoglobulins representing the target species. The Sanger sequences of the resistant colonies were used to determine the target species.
GJD2 markers by Boster Bio are high affinity primary antibodies that can be used to detect specific antigens. They have been cited over the past 25 years and have been validated on ELISA, immunohistochemistry, and western blot. Boster antibodies are used in many applications, including protein identification, antigen discovery, and molecular imagery.
These antibodies can be used to detect antigens in tissues and cells, not primary antibodies. To enhance their specificity, they can also be conjugated to biotin, fluorescent dyes or enzymes. Secondary antibodies can be used for other purposes, and can be used specifically to detect antigens. These antibodies are invaluable in many research areas.
PMID: 9753189 by Condorelli D.F., et al. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons.
PMID: 10876089 by Cicirata F., et al. Genomic organization and chromosomal localization of the mouse Connexin36 (mCx36) gene.