GJB6 Antibodies

AND GJB6 ELISA kits, GJB6 Proteins

Many biological assays use antibodies to detect GJB6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GJB6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GJB6 antibodies...

We validate the specificity of these antibodies to GJB6 by testing them on tissues known to express GJB6 positively and negatively. Browse below to find the GJB6 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GJB6 Infographic by Boster Bio

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GJB6 Overview

Facts about Gap junction beta-6 protein.

GJB6 3D structure. Source: alphafold

Gap junction beta-6 protein (GJB6)

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

Gene Information

Human
Gene Name:	GJB6
Uniprot:	O95452
Entrez:	10804

Family

Belongs to:

connexin family

Alternative Names

Connexin 30; connexin-30; CX30; CX30gap junction protein, beta 6; DFNA3B; DFNB1B; ectodermal dysplasia 2, hidrotic (Clouston syndrome); ED2; EDH; gap junction beta-6 protein; gap junction protein, beta 6 (connexin 30); gap junction protein, beta 6, 30kDa; GJB6; HEDDFNA3

Molecular Weight

Mass (kDA):
30.387 kDA

Genomic Context


Human

Location:	13q12.11
Sequence:	13; NC_000013.11 (20221962..20232395, complement)

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Diseases

Complete Hearing Loss
Sensorineural Hearing Loss (disorder)
Deafness Congenital
Ectodermal Dysplasia
Nodular Sclerosis Classical Hodgkin Lymphoma
Hidrotic Ectodermal Dysplasia
Deaf Mutism
Dermatologic Disorders
Dysplasia
Neoplasms
Dystrophy
Palmoplantar Keratosis

Malignant Neoplasms
Hyperkeratosis
Hearing Loss, Bilateral
Dystrophia Unguium
Usher Syndrome
Hereditary Diseases
Nervousness

Pathways

Localization
Pathogenesis
Transport
Mating
Lactation
Aging
Cell Proliferation
Cornification
Parturition
Echolocation
Synaptic Transmission
Regeneration
Cell Death

Cell Growth
Excretion
Secretion
Keratinization
Dna Hypermethylation
Cellular Homeostasis
Fertilization

PTMs

Demethylation

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GJB6

References

PMID: 10471490 by Grifa A., et al. Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus.

PMID: 10610709 by Kelley P.M., et al. Human connexin 30 (GJB6), a candidate gene for nonsyndromic hearing loss: molecular cloning, tissue-specific expression, and assignment to chromosome 13q12.