GJA8 Antibodies

AND GJA8 ELISA kits, GJA8 Proteins

Many biological assays use antibodies to detect GJA8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GJA8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GJA8 antibodies...

We validate the specificity of these antibodies to GJA8 by testing them on tissues known to express GJA8 positively and negatively. Browse below to find the GJA8 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GJA8 Infographic by Boster Bio

All GJA8 Products

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Product

Figures

Specificity

Applications

Price

GJA8 (NM_005267) Human Recombinant Protein

$813
Cat # PROTP48165
20 µg

GJA8 (NM_005267) Human Over-expression Lysate

Human

$960
Cat # LS002703
100 µg

GJA8 Overview

Facts about Gap junction alpha-8 protein.

GJA8 3D structure. Source: alphafold

Gap junction alpha-8 protein (GJA8)

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. .

Gene Information

Human
Gene Name:	GJA8
Uniprot:	P48165
Entrez:	2703

Family

Belongs to:

connexin family

Alternative Names

alpha 8, 50kD (connexin 50); CAE; CAE1; Connexin 50; Connexin-50; CX50; CZP1; gap junction alpha-8 protein; gap junction membrane channel protein alpha-8; gap junction protein, alpha 8, 50kDa (connexin 50); gap junction protein, alpha 8, 50kDa; GJA8; lens intrinsic membrane protein MP70; MP70

Molecular Weight

Mass (kDA):
48.229 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (147902795..147915287)

Tissue Specificity

Eye lens.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Diseases

Cataract
Nuclear Cataract
Microphthalmos
Senile Cataract
Corneal Diseases
Disorder Of Eye
Congenital Abnormality
Embryonal Nuclear Cataract (disorder)
Eye Abnormalities
Cytogenetic Abnormality

Lens Opacities
Congenital Lamellar Cataract
Myopia
Bilateral Cataracts (disorder)
Cholangiocarcinoma

Pathways

Transport
Eye Development
Cell Adhesion
Translation
Cell Death
Cell Differentiation
Cell Growth
Virulence

Pathogenesis
Localization
Cell Maturation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GJA8

References

PMID: 7796604 by Church R.L., et al. The human lens intrinsic membrane protein MP70 (Cx50) gene: clonal analysis and chromosome mapping.

PMID: 9497259 by Shiels A., et al. A missense mutation in the human connexin50 gene (GJA8) underlies autosomal dominant 'zonular pulverulent' cataract, on chromosome 1q.