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- Table of Contents
Facts about Gamma-glutamyl hydrolase.
May play an essential role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. .
Human | |
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Gene Name: | GGH |
Uniprot: | Q92820 |
Entrez: | 8836 |
Belongs to: |
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peptidase C26 family |
Conjugase; EC 3.4.19.9; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase; Gamma-Glu-X carboxypeptidase; GH
Mass (kDA):
35.964 kDA
Human | |
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Location: | 8q12.3 |
Sequence: | 8; NC_000008.11 (63015079..63038806, complement) |
Secreted, extracellular space. Lysosome. Melanosome. While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
PMID: 8816764 by Yao R., et al. Human gamma-glutamyl hydrolase: cloning and characterization of the enzyme expressed in vitro.
PMID: 10570974 by Yin D., et al. Structural organization of the human gamma-glutamyl hydrolase gene.