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GGA1 Antibodies
AND GGA1 ELISA kits, GGA1 Proteins
Many biological assays use antibodies to detect GGA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GGA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GGA1 antibodies...
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GGA1 Overview
Facts about ADP-ribosylation factor-binding protein GGA1.
ADP-ribosylation factor-binding protein GGA1 (GGA1)
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules using a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005, PubMed:15886016).
Mediates export of this GPCR receptor ADRA2B to the cell surface (PubMed:27901063). Required for targeting PKD1:PKD2 complicated in the trans-Golgi system to the cilium membrane (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | GGA1 |
| Uniprot: | Q9UJY5 |
| Entrez: | 26088 |
Family
| Belongs to: |
|---|
| GGA protein family |
Alternative Names
ADP-ribosylation factor binding protein 1; ADP-ribosylation factor-binding protein GGA1; gamma adaptin ear containing, ARF binding protein 1; gamma-adaptin related protein 1; Gamma-adaptin-related protein 1; golgi-associated, gamma adaptin ear containing, ARF binding protein 1; Golgi-localized, gamma ear-containing, ARF-binding protein 1
Molecular Weight
Mass (kDA):
70.384 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (37608474..37633564) |
Tissue Specificity
Ubiquitously expressed.
Subcellular Localizations
Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein.
Diseases
- Alzheimer's Disease
- Dysequilibrium Syndrome
- Senile Plaques
- Stomatitis
- Poultry Diseases
- Chimera Disorder
- Plaque, Amyloid
- Nerve Degeneration
- Vesicular Stomatitis
- Myocardial Ischemia
- Craniocerebral Trauma
- Ehrlichiosis Chafeensis (diagnosis)
Interacting Proteins
- Adra2b
- Arf6
- BACE1
- C1orf216
- DTNB
- GGA2
- GGA3
- IGF2R
- MON2
- RABEP1
Pathways
- Transport
- Localization
- Pathogenesis
- Intracellular Transport
- Endocytosis
- Secretion
- Secretory Pathway
- Endocytic Recycling
- Protein Transport
- Rna Interference
- Clathrin-mediated Endocytosis
- Asexual Sporulation
- Adiponectin Secretion
PTMs
- Ribosylation
- Phosphorylation
- Cleavage
Research Areas
- Cell Biology
- Golgi Apparatus Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GGA1
bosterbio.com/bosterbio-gene-info-cards/GGA1
References
PMID: 10749927 by Boman A.L., et al. A family of ADP-ribosylation factor effectors that can alter transport through the trans-Golgi.
PMID: 10747089 by Dell'Angelica E.C., et al. GGAs: a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex.