This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Germinal center-associated signaling and motility protein.
Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation leads to inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK.
Mouse | |
---|---|
Gene Name: | Gcsam |
Uniprot: | Q6RFH4 |
Entrez: | 14525 |
Belongs to: |
---|
No superfamily |
GAL; GCAT2; germinal center B-cell-expressed transcript 2 protein; germinal center expressed transcript 2; Germinal center-associated lymphoma protein; HGAL; MGC40441
Mass (kDA):
20.988 kDA
Mouse | |
---|---|
Location: | 16|16 B5 |
Sequence: | 16; |
Highly expressed in normal germinal center (GC) B-cells. Expressed in spleen and, to a lesser extent, bone marrow.
PMID: 7981148 by Christoph T., et al. M17: a novel gene expressed in germinal centers.
PMID: 23299888 by Romero-Camarero I., et al. Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.