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- Table of Contents
1 Citations 3 Q&As
2 Citations
Facts about Gamma-aminobutyric acid receptor-associated protein.
Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Human | |
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Gene Name: | GABARAP |
Uniprot: | O95166 |
Entrez: | 11337 |
Belongs to: |
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ATG8 family |
Apg8p1; ATG8A; FLC3B; FLJ25768; GABA(A) receptor-associated proteinMGC120154; GABARAP; gamma-aminobutyric acid receptor-associated protein; MM46; MM46MGC120155
Mass (kDA):
13.918 kDA
Human | |
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Location: | 17p13.1 |
Sequence: | 17; NC_000017.11 (7240008..7242449, complement) |
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas.
Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle. Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity).
PMID: 9892355 by Wang H., et al. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
PMID: 11146101 by Okazaki N., et al. Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
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