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- Table of Contents
1 Citations
Facts about Ras GTPase-activating protein-binding protein 1.
Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with similar efficiency (PubMed:9889278). Acts unidirectionally by moving in the 5' to 3' direction along the jump single-stranded DNA (PubMed:9889278).
Human | |
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Gene Name: | G3BP1 |
Uniprot: | Q13283 |
Entrez: | 10146 |
Belongs to: |
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No superfamily |
ATP-dependent DNA helicase VIII; EC 3.6.1; EC 3.6.4.12; EC 3.6.4.13; G3BP-1; G3BPRas-GTPase-activating protein SH3-domain-binding protein; GAP binding protein; GAP SH3 domain-binding protein 1; GTPase activating protein (SH3 domain) binding protein 1; hDH VIII; HDH-VIII; MGC111040; ras GTPase-activating protein-binding protein 1; RasGAP-associated endoribonuclease G3BP
Mass (kDA):
52.164 kDA
Human | |
---|---|
Location: | 5q33.1 |
Sequence: | 5; NC_000005.10 (151771954..151812785) |
Ubiquitous.
Cytoplasm, cytosol. Perikaryon. Cytoplasm, Stress granule. Nucleus. Cytoplasmic in proliferating cells (PubMed:11604510). Cytosolic and partially nuclear in resting cells (PubMed:11604510). Recruited to stress granules in response to arsenite treatment (PubMed:12642610, PubMed:20180778). The unphosphorylated form is recruited to stress granules (PubMed:12642610). HRAS signaling contributes to this process by regulating G3BP dephosphorylation (PubMed:12642610).
PMID: 8649363 by Parker F., et al. A Ras-GTPase-activating protein SH3-domain-binding protein.
PMID: 9889278 by Costa M., et al. Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway.
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