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- Table of Contents
Facts about F-box/WD repeat-containing protein 5.
May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, resulting in prevent centriole reduplication (By similarity).
Mouse | |
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Gene Name: | Fbxw5 |
Uniprot: | Q9QXW2 |
Entrez: | 30839 |
Belongs to: |
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FBXW5 family |
DKFZp434B205; F-box and WD repeat domain containing 5; F-box and WD-40 domain protein 5; F-box and WD-40 domain-containing protein 5; F-box/WD repeat-containing protein 5; Fbw5; MGC20962; RP11-229P13.10; WD repeat-containing F-box protein FBW5
Mass (kDA):
64.646 kDA
Mouse | |
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Location: | 2|2 A3 |
Sequence: | 2; |
Widely expressed in adult and embryonal tissues.
PMID: 10531037 by Winston J.T., et al. A family of mammalian F-box proteins.
PMID: 23314863 by Werner A., et al. SCF(Fbxw5) mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.