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- Table of Contents
Facts about F-box only protein 7.
Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.
Human | |
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Gene Name: | FBXO7 |
Uniprot: | Q9Y3I1 |
Entrez: | 25793 |
Belongs to: |
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No superfamily |
F-box only protein 7; F-box protein 7; FBX; FBX07; FBX7Fbx; PARK15DKFZp686B08113; PKPS
Mass (kDA):
58.503 kDA
Human | |
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Location: | 22q12.3 |
Sequence: | 22; NC_000022.11 (32474682..32498831) |
Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytosol. Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria.
PMID: 10945468 by Ilyin G.P., et al. cDNA cloning and expression analysis of new members of the mammalian F-box protein family.
PMID: 12529303 by Collins J.E., et al. Reevaluating human gene annotation: a second-generation analysis of chromosome 22.