Frizzled-8 Antibodies

Part of the Wnt-Fzd- LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes to ribosome- sized signalosomes. The beta-catenin canonical signaling pathway results in the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.

Another signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it isn't yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins.