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Frizzled-4 Antibodies
AND FZD4 ELISA kits, Frizzled-4 Proteins
Many biological assays use antibodies to detect Frizzled-4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Frizzled-4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Frizzled-4 antibodies...
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FZD4 Infographic by Boster Bio
All FZD4 Products
Product
Figures
Specificity
Applications
Price
Anti-Frizzled 4/FZD4 Antibody Picoband®
1 Citations 7 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # A02191-1
100 μg/vial
Cat # A02191-1
100 μg/vial
FZD4 Overview
Facts about Frizzled-4.
Frizzled-4 (FZD4)
Receptor for Wnt proteins.
Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the regeneration of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes.Plays a crucial role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it may be equally activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), boosting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs.
Gene Information
| Human | |
|---|---|
| Gene Name: | FZD4 |
| Uniprot: | Q9ULV1 |
| Entrez: | 8322 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor Fz/Smo family |
Alternative Names
CD344 antigen; CD344; EVR1; exudative vitreoretinopathy 1; FEVR; frizzled (Drosophila) homolog 4; frizzled homolog 4 (Drosophila); Frizzled4; Frizzled-4; Fz-4; FZD4; FZD4S; FzE4; GPCR; hFz4; MGC34390; WNT receptor frizzled-4
Molecular Weight
Mass (kDA):
59.881 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q14.2 |
| Sequence: | 11; NC_000011.10 (86945679..86955395, complement) |
Tissue Specificity
Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Retinal Diseases
- Tumor Angiogenesis
- Malignant Neoplasms
- Proliferative Vitreoretinopathy
- Neoplasms
- Pathologic Neovascularization
- Norrie Disease
- Disorder Of Eye
- Blind Vision
- Eye Diseases, Hereditary
- Retinal Detachment
- Retinopathy Of Prematurity
Interacting Proteins
- NDP
Pathways
- Angiogenesis
- Cell Proliferation
- Pathogenesis
- Cell Adhesion
- Cell Fate Determination
- Localization
- Clathrin-mediated Endocytosis
- Lung Development
- Glycosylation
- Regeneration
- Transport
- Pigmentation
- Cell Cycle
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FZD4
bosterbio.com/bosterbio-gene-info-cards/FZD4
References
PMID: 10544037 by Kirikoshi H., et al. Molecular cloning and characterization of human frizzled-4 on chromosome 11q14-q21.
PMID: 9707618 by Tanaka S., et al. A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals.
1 Publications of Boster Frizzled-4 Antibodies & ELISA Kits
- PubMed ID: 34021822, Li X,Lv J,Hou L,Guo X. Circ_0001955 Acts as a miR-646 Sponge to Promote the Prol...
*More publications can be found for each product on its corresponding product page