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- Table of Contents
Facts about Frizzled-3.
Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism.
Human | |
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Gene Name: | FZD3 |
Uniprot: | Q9NPG1 |
Entrez: | 7976 |
Belongs to: |
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G-protein coupled receptor Fz/Smo family |
frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); Frizzled3; Frizzled-3; Fz-3; FZD3; hFz3
Mass (kDA):
76.263 kDA
Human | |
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Location: | 8p21.1 |
Sequence: | 8; NC_000008.11 (28494205..28574268) |
Widely expressed. Relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis.
Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cell surface. Apical cell membrane; Multi-pass membrane protein. Colocalizes with FZD6 at the apical face of the cell (By similarity).
Boster Bio offers high-affinity primary antibodies against the FZD3 marker. These antibodies recognize Frizzled-3 as a susceptibility locus in schizophrenia. The company also offers educational material and PDFs that can be used by educators. If you use the resources for your own research, please link to the source and properly cite them. Boster Bio's educational materials are meant to be shared with educators. Make sure you link to them whenever you use them.
You have found the right place to find anti-Frizzled-3 antibodies. Boster Bio provides high-affinity primary antibodies that have been thoroughly validated on several platforms, including Western Blotting, Immunohistochemistry, and ELISA. Boster Bio can provide you with a single antibody or a set of monoclonal antibodies.
Many suppliers offer anti FZD3 antibodies. These antibodies are specific to frizzled-3, also known as FZD3, Frizzled-3, and Fz-3. This transmembrane proteins is 76.3 Kilodaltons in weight and has orthologs within the canine and mouse species. These monoclonal antibodies are ideal for research applications, as they can recognize multiple targets in a single cell.
The two primary antibodies, 2A2 and BT-1, bind Fc-hROR1 in a concentration-dependent manner. Monovalent BT-1 bound Fc-hROR1 in a concentration-dependent manner while bivalent BT-1 and hROR2-Fc had a lower KD value. These monovalent antibodies might be useful for the creation of new ROR1 immunotoxins.
Researchers have found a link between chromosomes 8p21-22 (a susceptibility locus) and FZD3 (a susceptibility to psychosis). Fine mapping was used for the identification and verification of the susceptibility genes. It involved finding disequilibrium in linkage between genetic markers in a three-person sample and one in a controlled case. Voxelbased morphometry was also used to identify schizophrenia-associated alleles.
The gene encodes a seven domain transmembrane protein. The protein is a receptor of the wingless type MMTV site family. Frizzled protein might be involved with hair follicle growth. The risk of schizophrenia is also linked to this gene. Further research is needed for confirmation of its role in schizophrenia. The susceptibility gene for schizophrenia is associated with higher levels of frizzled Protein.
Genetic linkage studies showed a link in genetic linkage studies between schizophrenia in Asians and a genetic variant from the human frizzeled3 genome. However, this was not seen in Caucasians. Researchers have genotyped single nucleotide variants in FZD3 genes and examined the haplotypes from FZD3 mutants. These analyses did NOT reveal significant associations. FZD3 might not be a factor in schizophrenia predisposition in the Caucasian population.
In both case-control and trio samples, schizophrenia was linked to PCM1 polymorphisms. This locus is also associated with a decreased volume of gray matter within the temporal pole and inferior cortex in schizophrenia not caused by PCM1. Further studies are required to confirm the link between the three PCM1 Polymorphisms with schizophrenia in family and case-control samples.
However, genetic studies of humans have been very limited. While some genetic markers were linked to schizophrenia, others weren't. This is because schizophrenia and bipolar disorder do not share the same genetic etiology. Family studies of schizophrenia have been done in other studies. This suggests that they may share a common genetic susceptibility. Genetic linkage analysis has also proven to be limited in schizophrenia cases, with some researchers concluding that schizophrenia and bipolar disorder have different genetic etiologies.
Genetic studies have not produced consistent results for FZD3 gene. Additional genetic studies on FZD3 could help to identify the genetic link between schizophrenia, and other psychotic disorders. They could also provide valuable information on Fzd3's role in the Wnt cascade. With all these benefits, the scientific community has great potential to benefit from the study and investigation of schizophrenia.
Research in this area has shown the FZD3 gene is involved with the development of neuronal connectivity. This could be a function. Kirikoshi and his collaborators suggested that FZD3 might play a role in embryogenesis. The FZD3 gene is present in various cell types, including neural, glial, and eukaryotic. The FZD3 genes may also play a role in neurogenesis.
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PMID: 10777673 by Kirikoshi H., et al. Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21.
PMID: 10873558 by Sala C.F., et al. Identification, gene structure and expression of human frizzled-3 (FZD3).