FRS2 Antibodies

AND FRS2 ELISA kits, FRS2 Proteins

Many biological assays use antibodies to detect FRS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FRS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FRS2 antibodies...

We validate the specificity of these antibodies to FRS2 by testing them on tissues known to express FRS2 positively and negatively. Browse below to find the FRS2 antibody that suites your experiment. We have 7 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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FRS2 Infographic by Boster Bio

All FRS2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-FRS2 Monoclonal Antibody

3 Q&As

Human

Flow Cytometry, IP, WB

$370
Cat # M02798
100 μl

FRS2 Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$480
Cat # EKC1226
1 kit, containing one 96-well plate and all necessary reagents

FRS2 (Phospho-Tyr436) Colorimetric Cell-Based ELISA Kit

Human, Mouse

ELISA

$540
Cat # EKC2597
1 kit, containing two 96-well plates and all necessary reagents

Anti-Phospho-FRS2 (Y436) Antibody

Human, Monkey, Mouse

ELISA, IHC, WB

$380
Cat # A02798Y436
100ul

Anti-FRS2 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A02798
100ul

FRS2 (NM_006654) Human Recombinant Protein

$813
Cat # PROTQ8WU20
20 µg

FRS2 (NM_006654) Human Over-expression Lysate

Human

$628
Cat # LS010818
100 µg

FRS2 Overview

Facts about Fibroblast growth factor receptor substrate 2.

FRS2 3D structure. Source: alphafold

Fibroblast growth factor receptor substrate 2 (FRS2)

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3- kinase, in reaction to ligand-mediated activation of FGFR1.

Modulates indicating via SHC1 by competing for a common binding site on NTRK1. .

Gene Information

Human
Gene Name:	FRS2
Uniprot:	Q8WU20
Entrez:	10818

Family

Belongs to:

No superfamily

Alternative Names

FGFR signalling adaptor; FGFR-signaling adaptor SNT; fibroblast growth factor receptor substrate 2; FRS2; FRS2A; FRS2alpha; SNT; SNT1; SNT-1FGFR substrate 2; Suc1-associated neurotrophic factor target 1

Molecular Weight

Mass (kDA):
57.029 kDA

Genomic Context


Human

Location:	12q15
Sequence:	12; NC_000012.12 (69470371..69579793)

Tissue Specificity

Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Subcellular Localizations

Endomembrane system. Cytoplasmic, membrane-bound.

Diseases

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Tumor Angiogenesis
Neuroblastoma
Carcinoma
Malignant Paraganglionic Neoplasm
Tissue Adhesions
Malignant Neoplasm Of Breast
Mammary Neoplasms
Endocrine Gland Neoplasms
Multiple Endocrine Neoplasia
Nervousness

Lung Neoplasms
Prostatic Neoplasms
Multiple Endocrine Neoplasia Type 2a
Chimera Disorder
Pheochromocytoma
Chromosomal Translocation
Neoplasm Metastasis

Interacting Proteins

PTPN11

Pathways

Cell Proliferation
Localization
Angiogenesis
Cell Migration
Cell Growth
Cell Differentiation
Cell Cycle
Cell Death
Tube Formation
Chemotaxis
Cell Adhesion
Mesoderm Formation
Ossification

Chondrocyte Proliferation
Sulfation
Glycosylation
Oocyte Maturation
Regeneration
Endothelial Cell Migration
Mapk Cascade

PTMs

Phosphorylation
Ubiquitination

Glycosylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FRS2

References

PMID: 9660748 by Xu H., et al. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins.

PMID: 10092678 by Meakin S.O., et al. The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation.