This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
Forkhead box protein L2 Antibodies
AND FOXL2 ELISA kits, Forkhead box protein L2 Proteins
Many biological assays use antibodies to detect Forkhead box protein L2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Forkhead box protein L2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Forkhead box protein L2 antibodies...
Previous: BFSP1
Next: BPGM
FOXL2 Infographic by Boster Bio
All FOXL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # A01185-1
100 μg/vial
Cat # A01185-1
100 μg/vial
FOXL2 Overview
Facts about Forkhead box protein L2.
Forkhead box protein L2 (FOXL2)
Transcriptional regulator. Crucial factor necessary for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination.
Prevents trans- differentiation of ovary to testis via transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXL2 |
| Uniprot: | P58012 |
| Entrez: | 668 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BPES; BPES1; BPES1PINTO; forkhead box L2; forkhead box protein L2; forkhead transcription factor FOXL2; FOXL2; PFRK; PINTO; POF3
Molecular Weight
Mass (kDA):
38.772 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q22.3 |
| Sequence: | 3; NC_000003.12 (138944224..138947137, complement) |
Tissue Specificity
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
Subcellular Localizations
Nucleus.
Diseases
- Premature Menopause
- Blepharophimosis
- Ovarian Failure, Premature
- Blepharoptosis
- Neoplasms
- Turner Syndrome
- Granulosa Cell Tumor
- Ovarian Neoplasm
- Malignant Neoplasms
- Disorders Of Sex Development
- Congenital Epicanthus
- Infertility
Pathways
- Sex Determination
- Sex Differentiation
- Pathogenesis
- Localization
- Cell Differentiation
- Cell Proliferation
- Female Sex Determination
- Transdifferentiation
- Granulosa Cell Differentiation
- Meiosis
- Hatching
- Fertilization
- Gonad Development
PTMs
- Phosphorylation
- Sumoylation
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXL2
bosterbio.com/bosterbio-gene-info-cards/FOXL2
References
PMID: 11175783 by Crisponi L., et al. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome.
PMID: 16153597 by Lee K., et al. Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.
1 Publications of Boster Forkhead box protein L2 Antibodies & ELISA Kits
- PubMed ID: 10.1158/1078-0432.CCR-16-2180, HMGA2–FOXL2 Axis Regulates Metastases and Epithelial-to-Mesenchymal Transition...
*More publications can be found for each product on its corresponding product page