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FOXA1 Antibodies
AND FOXA1 ELISA kits, FOXA1 Proteins
Many biological assays use antibodies to detect FOXA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with FOXA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop FOXA1 antibodies...
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FOXA1 Infographic by Boster Bio
All FOXA1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, WB
$486
Cat # M00266
100ug/vial
Cat # M00266
100ug/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M00266-1
100 μl
Cat # M00266-1
100 μl
FOXA1 Overview
Facts about Hepatocyte nuclear factor 3-alpha.
Hepatocyte nuclear factor 3-alpha (FOXA1)
Transcription factor that's involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to serve as a'pioneer' variable opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter websites.
Binds DNA using the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs.
Gene Information
| Human | |
|---|---|
| Gene Name: | FOXA1 |
| Uniprot: | P55317 |
| Entrez: | 3169 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
forkhead box A1; Forkhead box protein A1; FoxA1; hepatocyte nuclear factor 3, alpha; hepatocyte nuclear factor 3-alpha; HNF3 alpha; HNF-3 alpha; HNF-3A; HNF-3-alpha; HNF3ATCF-3A; MGC33105; TCF3A; Transcription factor 3A
Molecular Weight
Mass (kDA):
49.148 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q21.1 |
| Sequence: | 14; NC_000014.9 (37589552..37595249, complement) |
Tissue Specificity
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Prostate
- Carcinoma
- Liver Carcinoma
- Prostatic Neoplasms
- Neoplasm Metastasis
- Adenocarcinoma
- Cell Transformation, Neoplastic
- Liver Neoplasms
Interacting Proteins
- AR
Pathways
- Cell Differentiation
- Secretion
- Cell Growth
- Cell Proliferation
- Cell Cycle
- Localization
- Pathogenesis
- Regulation Of Gene Expression
- Glucose Homeostasis
- Methylation
- Liver Development
- Insulin Secretion
- Chromatin Remodeling
PTMs
- Phosphorylation
- Methylation
- Acetylation
- Demethylation
Research Areas
- Breast Cancer
- Cancer
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FOXA1
bosterbio.com/bosterbio-gene-info-cards/FOXA1
References
PMID: 8652662 by Bingle C.D., et al. Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line.
PMID: 10899756 by Navas M.A., et al. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.