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- Table of Contents
Facts about Peptidyl-prolyl cis-trans isomerase FKBP8.
The BCL2/FKBP8/calmodulin/calcium complex likely interferes with the binding of BCL2 to its own targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity).
Mouse | |
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Gene Name: | Fkbp8 |
Uniprot: | O35465 |
Entrez: | 14232 |
Belongs to: |
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No superfamily |
38 kDa FK506-binding protein; EC 5.2.1.8,38 kDa FKBP; FK506 binding protein 8, 38kDa; FK506-binding protein 8 (38kD); FK506-binding protein 8; FKBP38; FKBP-38; FKBP38PPIase FKBP8; FKBP8; FKBP-8; FKBPr38; hFKBP38; peptidyl-prolyl cis-trans isomerase FKBP8; rotamase
Mass (kDA):
43.529 kDA
Mouse | |
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Location: | 8|8 B3.3 |
Sequence: | 8; |
Detected throughout the embryonic body, in caudal neural tube, limbs and head. Detected in adult retina, brain, heart, kidney, liver, pancreas, lung, testis and urinary bladder (at protein level). Detected in adult brain, kidney, liver, testis and trigeminal nerve, and in embryo. Detected at lower levels in lung, spleen, heart and ovary. Widely expressed in forebrain. Detected in the Purkinje cell layer in the cerebellum and in hippocampus neurons.
PMID: 12510191 by Shirane M., et al. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis.
PMID: 15105374 by Bulgakov O.V., et al. FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues.