FIS1 Antibodies

Mitochondrial fission 1 protein (FIS1)

Involved from the fragmentation of the mitochondrial system and its perinuclear clustering. Plays a minor part in the recruitment and institution of the fission mediator dynamin- associated protein 1 (DNM1L) into the mitochondrial surface and mitochondrial fission.

Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

Gene Information

Human
Gene Name:	FIS1
Uniprot:	Q9Y3D6
Entrez:	51024

Family

Belongs to:
FIS1 family

Alternative Names

CGI-135; FIS1 homolog; Fis1; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); H_NH0132A01.6; hFis1; mitochondrial fission 1 protein; tetratricopeptide repeat domain 11; Tetratricopeptide repeat protein 11; TTC11TPR repeat protein 11

Molecular Weight

Mass (kDA):
16.938 kDA

Genomic Context

Human
Location:	7q22.1
Sequence:	7; NC_000007.14 (101239472..101245081, complement)

Subcellular Localizations

Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.

Diseases

• Atrophy
• Malignant Neoplasms
• Parkinson Disease
• Neurodegenerative Disorders
• Optic Atrophy
• Alzheimer's Disease
• Multiple Endocrine Neoplasia
• Optic Atrophy, Autosomal Dominant
• Diabetes Mellitus
• Nerve Degeneration
• Hypoxia
• Neoplasms
• Plant Diseases

• Impaired Cognition
• Myocardial Infarction
• Anoxia
• Neuroblastoma
• Mitochondrial Diseases
• Charcot-marie-tooth Disease
• Ischemia

Interacting Proteins

• BCAP31
• CCDC155
• MIEF1
• NOD2

Pathways

• Mitochondrial Fission
• Cell Death
• Mitochondrial Fusion
• Autophagy
• Pathogenesis
• Seed Development
• Membrane Fission
• Organelle Fission
• Transport
• Programmed Cell Death
• Rna Interference
• Fertilization
• Aging

• Oxidative Phosphorylation
• Localization
• Endosperm Development
• Cell Growth
• Regulation Of Mitochondrial Fission
• Peroxisome Fission
• Senescence

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination

• Sumoylation
• Nitrosylation
• Methylation

Research Areas

• Apoptosis
• Cancer
• Mitochondrial Fusion Proteins
• Tumor Suppressors

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/FIS1

Boster Bio Review - Best Uses Of The FIS1 Marker

This Boster Bio review will discuss the Mitochondrial fission 1 (FIS1) protein, the advantages of the FIS1 marker, and some common problems users may experience. You will learn how to use this marker and how to troubleshoot Boster Bio. This review is intended for scientists worldwide, and should help you make the best use of Boster. We hope this review has been helpful.

Boster Bio

The FIS1 marker from Boster has been used for over 20 years for the analysis of human tissue samples. It has many applications within the scientific community, including DNA manipulation and investigation. Boster's product features comprehensive technical resources, blogs, and disease information. The lysis buffers that Boster provides are of high quality and designed to reduce cross-linking intensity and ensure good results.

Developed for the highest affinity in ELISA and WB applications, Boster antibodies have been validated against a panel of over 250 tissues. The antibodies have also been validated quantitatively against known quantities of recombinant proteins, enabling accurate and reliable results. The company's products are supported by unmatched customer service, allowing them to meet the specific requirements of any scientist.

Mitochondrial fission 1 protein (FIS1)

The FIS1 gene is located on chromosome 7 at 7q22.1 and encodes a protein that plays a critical role in the regulation of mitochondrial morphology and fission. Fis1 also plays a role in peroxisomal fission. In addition to mediating mitochondrial fission, this protein is also involved in the regulation of the cell cycle and apoptosis. It has been implicated in neurodegenerative diseases.

A microwell-based strip plate ELISA kit based on FIS-1 antibody-antigen interactions is designed to detect native FIS-1 in undiluted body fluids, tissue homogenates, and secretions. Molecular markers for FIS1 can be used in research and clinical settings to study mitochondrial function and dysfunction. This product is applicable to scientists around the world.

Benefits of using the FIS1 Marker

Using the FIS1 Marker in PCR Assays is a useful way to study the role of FIS1 in cell survival. Several knockout strains of this gene have secondary mutations that impair their ability to survive. In addition, three independently derived FIS1 knockout strains all acquired a loss-of-function mutation in WHI2.

The FIS1 marker is a DNA sequence that accompanies flanking sequences of the FIS1 gene. It is associated with the KanMX4 and URA3 cassettes, and is used in combination with other DNA sequences to study gene expression. These sequences have been shown to play a key role in the regulation of oxidative stress in cell survival. The FIS1 marker has many other advantages as well.