F-box only protein 5 (FBXO5)

Regulator of APC activity during mitotic and meiotic cell cycle (PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029). During mitotic cell cycle plays a role as both substrate and inhibitor of APC- FZR1 complicated (PubMed:29875408, PubMed:17485488, PubMed:17234884, PubMed:17875940, PubMed:23708001, PubMed:23708605, PubMed:16921029).

During G1 phase, plays a role as portion of APC-FZR1 complicated E3 ligase (PubMed:29875408). Then switches as an inhibitor of APC-FZR1 complicated during S and G2 resulting in cell- cycle commitment (PubMed:29875408).