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- Table of Contents
Facts about FAS-associated factor 2.
Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223). .
Human | |
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Gene Name: | FAF2 |
Uniprot: | Q96CS3 |
Entrez: | 23197 |
Belongs to: |
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No superfamily |
B17.2L; ETEAFAS-associated factor 2; expressed in T-cells and eosinophils in atopic dermatitis; Fas associated factor family member 2; KIAA0887UBX domain protein 3B; MMTN; NDUNDUFA12L; UBX domain containing 8; UBX domain-containing protein 3B; UBX domain-containing protein 8; UBXD8; UBXN3BProtein ETEA
Mass (kDA):
52.623 kDA
Human | |
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Location: | 5q35.2 |
Sequence: | 5; NC_000005.10 (176448328..176510074) |
Broadly expressed, with highest levels in brain.
Cytoplasm. Lipid droplet. Endoplasmic reticulum.
PMID: 12372427 by Imai Y., et al. Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients.
PMID: 18711132 by Mueller B., et al. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins.