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- Table of Contents
Facts about Endosome-associated-trafficking regulator 1.
Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).
Human | |
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Gene Name: | ENTR1 |
Uniprot: | Q96C92 |
Entrez: | 10807 |
Belongs to: |
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ENTR1 family |
Endosome-associated-trafficking regulator 1
Mass (kDA):
47.961 kDA
Human | |
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Location: | 9q34.3 |
Sequence: | 9; NC_000009.12 (136401922..136410614, complement) |
Cytoplasm. Early endosome. Endosome. Recycling endosome. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Colocalizes in a WASHC2-dependent manner with the retromer CSC complex at endosomes (PubMed:25278552). During cytokinesis colocalized with PTPN13 at the midbody (PubMed:23108400). Colocalizes with IFT88 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with IFT88 and pericentrin at the centrosome (PubMed:27767179).
PMID: 9610721 by Scanlan M.J., et al. Characterization of human colon cancer antigens recognized by autologous antibodies.
PMID: 23108400 by Hagemann N., et al. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis.