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- Table of Contents
Facts about Exosome complex component RRP43.
The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is included in overall mRNA turnover and especially degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.
Human | |
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Gene Name: | EXOSC8 |
Uniprot: | Q96B26 |
Entrez: | 11340 |
Belongs to: |
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RNase PH family |
bA421P11.3; CBP-interacting protein 3; CIP3; EAP2; exosome complex exonuclease RRP43; exosome component 8Opa-interacting protein 2; OIP2Ribosomal RNA-processing protein 43; Opa interacting protein 2; p9RP11-421P11.3; RRP43OIP-2; Rrp43p
Mass (kDA):
30.04 kDA
Human | |
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Location: | 13q13.3 |
Sequence: | 13; NC_000013.11 (37000373..37009614) |
Cytoplasm. Nucleus. Nucleus, nucleolus.
PMID: 9466265 by Williams J.M., et al. Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth.
PMID: 11719186 by Chen C.-Y., et al. AU binding proteins recruit the exosome to degrade ARE-containing mRNAs.