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Facts about Exosome complex component RRP40.
The RNA exosome could be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination action to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in overall mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) in their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs.
Human | |
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Gene Name: | EXOSC3 |
Uniprot: | Q9NQT5 |
Entrez: | 51010 |
Belongs to: |
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RRP40 family |
bA3J10.7; CGI-102; exosome complex exonuclease RRP40; exosome component 3MGC15120; exosome component Rrp40; hRrp-40; hRrp40p; p10Rrp40p; Ribosomal RNA-processing protein 40; RP11-3J10.8; RRP40MGC723
Mass (kDA):
29.572 kDA
Human | |
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Location: | 9p13.2 |
Sequence: | 9; NC_000009.12 (37779714..37785092, complement) |
Cytoplasm. Nucleus, nucleolus. Nucleus.
This article will talk about the Boster Bio Anti–EXOSC3 Marker. It is a high-affinity, primary antibody with clinical application. We will discuss differences between Rat, Mouse, Human antibodies and their biological activity. We will also be discussing the benefits of the Boster Bio Anti EXOSC3 marker. If you're looking for a high-affinity antibody, Boster Bio has a wide variety of options to suit your needs.
Boster Bio's Anti EXOSC3 antibody reacts to human, mouse and rat. Boster's antibodies are widely cited in research communities, making them reliable antibodies for a wide range of applications. Here are a few examples of how the antibody can be used in research. Here is a list of some of most popular uses for this antibody.
The primary antibody to the exosome complex is the Boster Anti-EXOSC3 marker. This gene encodes an exosome non-catalytic part. The exosome is important in RNA processing. It is found on the chromosomes 20 and 21. Boster antibodies are widely used in research and have been validated.
High-affinity antibodies are highly specific for antigens. However this is not always desirable. This affinity can make it hard to separate the antibody and antigen, making the affinity column elution more difficult. These issues can be avoided by using next-generation immunoassays. Here are some of those high-affinity primaries antibodies that have many benefits.
A high-affinity antibody is a B cell with a higher affinity to a given antigen. These antibodies were four times more effective in producing high-affinity antibodies than those produced from mice that had low-affinity. High-affinity b cells responded twice as strongly to NP Ficoll than low-affinity b cells. Competition experiments only confirmed that high-affinity b cells respond to the antigen. Using mice with a CD19 deficiency boosted the affinity threshold for TI-2 responses. Lyn deficiency in mice resulted in B cell terminal differentiation being halted and an increase in the affinity threshold for TI-2 responses.
In vitro the RNA exosome interacts with AID to mediate robust degradation of transcribed SHM Substrates. Deficiency in Exosc3/Exosc10 affects SHM and CSR. A transcriptome analysis of B cells deficient in Exosc3 or Exosc10 reveals that lncRNAs can be targeted by the Exosome.
The 15062-1-AP high-affinity primary antibody 15062-1-AP targets the EXOSC3 proteins and exhibit excellent reactivity with mouse, human, rat, and mouse specimens. The antibodies were incubated overnight at 4C. The Exosc3 level had dropped after depletion. The ELISA cannot detect the protein if this marker is removed.
The EXOSC3 marker is a novel molecular marker in a number of cancers, including prostate and colorectal cancer. The gene encodes a protein which is expressed in tumor microenvironment. EXOSC3 inhibits the G1/S transformation in cancer cells and promotes growth in CRC. This marker can be used to diagnose CRC and other cancers.
A case study involving an 8-year-old girl who had been floppy since childhood developed progressive respiratory failure, a nasogastric tube for enteral nutrition, and a clinical suspicion of peripheral hypotonia. Electromyography revealed a neuropathic pattern, and her karyotype was 46, XX. Single-gene SMN1 test was negative. The diagnosis of spinal muscular atrophies type 1 was not made. PCH type I was diagnosed by the patient's ventriculomegaly. Also, the homozygous Missense mutation in exon 1, EXOSC3 gene, was used.
The gene's importance in development has been highlighted by several studies. It plays a crucial role in proper muscle movement. It also appears to protect motor neurons in the spinal cord, which are important for coordinated movement. These studies have led to new diagnostic tools that are now available to clinicians. The clinical applications of the EXOSC3 marker are numerous and growing. These results further support the idea that the EXOSC3 marker plays a wide and varied role in the development of genetic disorders in patients.
Analysis of mutation frequencies indicated that EXOSC3-related mutations were more common among the five most common types. KIRC had a higher incidence of mutations than any other types. Additional information was also included in the revised manuscript. The figures showing photographs of tumor mass should be included along with the analysis. Additional information should be provided in addition to the plots of figure 6.
While the EXOSC3 gene encodes the EXOSC3 component of human exosome, it has been implicated in breast cancer metastasis. Goodarzi and al. used EXOSC3 diagnostic tools. Transfer RNAs can promote breast cancer metastasis through directly increasing EXOSC2 gene expression, as Goodarzi et al. Moreover, Bauer et al. Bauer et al.
PMID: 11110791 by Brouwer R., et al. Three novel components of the human exosome.
PMID: 10465791 by Allmang C., et al. The yeast exosome and human PM-Scl are related complexes of 3'-->5' exonucleases.