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Exonuclease 1 Antibodies
AND EXO1 ELISA kits, Exonuclease 1 Proteins
Many biological assays use antibodies to detect Exonuclease 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Exonuclease 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Exonuclease 1 antibodies...
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EXO1 Infographic by Boster Bio
All EXO1 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A00536-2
100 μg/vial
Cat # A00536-2
100 μg/vial
EXO1 Overview
Facts about Exonuclease 1.
Exonuclease 1 (EXO1)
5'->3' double-stranded DNA exonuclease which may also have a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch- containing DNA tracts led by strand breaks located either 5' or 3' to the mismatch.
Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes.
Gene Information
| Human | |
|---|---|
| Gene Name: | EXO1 |
| Uniprot: | Q9UQ84 |
| Entrez: | 9156 |
Family
| Belongs to: |
|---|
| XPG/RAD2 endonuclease family |
Alternative Names
EXOI; exonuclease 1; Exonuclease I; HEX1rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1; hExo1; hExoIEC 3.1
Molecular Weight
Mass (kDA):
94.103 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43 |
| Sequence: | 1; NC_000001.11 (241847967..241889939) |
Tissue Specificity
Highly expressed in bone marrow, testis and thymus. Expressed at lower levels in colon, lymph nodes, ovary, placenta, prostate, small intestine, spleen and stomach.
Subcellular Localizations
Nucleus. Colocalizes with PCNA to discrete nuclear foci in S-phase.
Diseases
- Malignant Neoplasms
- Neoplasms
- Colorectal Cancer
- Genomic Instability
- Hereditary Nonpolyposis Colorectal Cancer
- Colorectal Neoplasms
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Carcinoma
- Microsatellite Instability
- Ataxia Telangiectasia
- Cell Invasion
Interacting Proteins
- MSH2
- RBBP8
Pathways
- Mismatch Repair
- Dna Repair
- Dna Replication
- Cell Cycle
- Meiosis
- Gene Conversion
- Double-strand Break Repair
- Cell Cycle Arrest
- Dna Damage Checkpoint
- Dna Recombination
- S Phase
- Telomere Maintenance
- Telomere Capping
PTMs
- Phosphorylation
- Cleavage
- Methylation
Research Areas
- Apoptosis
- Cancer
- Core ESC-Like Genes
- DNA Repair
- Editing and Processing Endonucleases
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EXO1
bosterbio.com/bosterbio-gene-info-cards/EXO1
References
PMID: 9788596 by Schmutte C., et al. Human exonuclease I interacts with the mismatch repair protein hMSH2.
PMID: 9823303 by Tishkoff D.X., et al. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.