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EIF3H Antibodies
AND EIF3H ELISA kits, EIF3H Proteins
Many biological assays use antibodies to detect EIF3H, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EIF3H in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EIF3H antibodies...
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EIF3H Overview
Facts about Eukaryotic translation initiation factor 3 subunit H.
Eukaryotic translation initiation factor 3 subunit H (EIF3H)
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC).
The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632).
Gene Information
| Human | |
|---|---|
| Gene Name: | EIF3H |
| Uniprot: | O15372 |
| Entrez: | 8667 |
Family
| Belongs to: |
|---|
| eIF-3 subunit H family |
Alternative Names
eIF-3-gamma; eIF3-gamma; eIF3h; eIF3-p40; EIF3S3eIF3 p40 subunit; Eukaryotic translation initiation factor 3 subunit 3; eukaryotic translation initiation factor 3 subunit H; eukaryotic translation initiation factor 3, subunit 2 (beta, 36kD); eukaryotic translation initiation factor 3, subunit 3 (gamma, 40kD); eukaryotic translation initiation factor 3, subunit 3 gamma, 40kDa; eukaryotic translation initiation factor 3, subunit H; MGC102958
Molecular Weight
Mass (kDA):
39.93 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q23.3-q24.11 |
| Sequence: | 8; NC_000008.11 (116642130..116755823, complement) |
Subcellular Localizations
Cytoplasm.
Diseases
- Malignant Neoplasms
- Colorectal Neoplasms
- Colorectal Cancer
- Hepatitis
- Hepatitis C
- Muscle Spasticity
- Malignant Neoplasm Of Prostate
- Microcephaly
- Cell Transformation, Neoplastic
- Adenoma
- Lung Neoplasms
Interacting Proteins
- ABI3
- DISC1
- EIF3B
- EIF3CL
- EIF3F
- EIF3M
- NCK2
Pathways
- Translation
- Pollen Germination
- Cell Growth
- Germination
- Pathogenesis
- Protein Phosphorylation
- Regulation Of Viral Transcription
- Pollen Maturation
- Cell Proliferation
- Pollen Development
- Induction Of Apoptosis
- Cell Development
- Proteolysis
PTMs
- Phosphorylation
Research Areas
- Angiogenesis
- Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EIF3H
bosterbio.com/bosterbio-gene-info-cards/EIF3H
References
PMID: 9341143 by Asano K., et al. Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly.
PMID: 16286006 by Holz M.K., et al. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events.