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- Table of Contents
3 Citations 17 Q&As
7 Citations 5 Q&As
Facts about Eukaryotic translation initiation factor 2-alpha kinase 3.
Serves as a critical effector of unfolded protein response (UPR)- induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
Human | |
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Gene Name: | EIF2AK3 |
Uniprot: | Q9NZJ5 |
Entrez: | 9451 |
Belongs to: |
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protein kinase superfamily |
DKFZp781H1925; EC 2.7.11.1; EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3; eukaryotic translation initiation factor 2-alpha kinase 3; hsPEK; PEK; PEKPERKPancreatic eIF2-alpha kinase; PERK; PRKR-like endoplasmic reticulum kinase; WRS
Mass (kDA):
125.216 kDA
Human | |
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Location: | 2p11.2 |
Sequence: | 2; NC_000002.12 (88556740..88627464, complement) |
Ubiquitous. A high level expression is seen in secretory tissues.
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
PMID: 10026192 by Shi Y., et al. Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
PMID: 10677345 by Sood R., et al. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress.
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