Eukaryotic translation initiation factor 2-alpha kinase 1 (Eif2ak1)

Inhibits protein synthesis in the translation initiation degree, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its role through the phosphorylation of EIF2S1 in'Ser- 48' and'Ser-51', thus preventing its recycling.

Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration inside the cell.