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EID1 Antibodies
AND EID1 ELISA kits, EID1 Proteins
Many biological assays use antibodies to detect EID1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EID1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EID1 antibodies...
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EID1 Overview
Facts about EP300-interacting inhibitor of differentiation 1.
EP300-interacting inhibitor of differentiation 1 (EID1)
Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation.
Inhibits EP300 and CBP histone acetyltransferase activity.May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory variable for NR0B2 which may be directly connected to transcription inhibitory mechanisms.
Gene Information
| Human | |
|---|---|
| Gene Name: | EID1 |
| Uniprot: | Q9Y6B2 |
| Entrez: | 23741 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
21 kDa pRb-associated protein; C15orf3PTD014; CREBBP/EP300 inhibitor 1; CREBBP/EP300 inhibitory protein 1MGC138884; CRI1EP300-interacting inhibitor of differentiation 1; E1A-like inhibitor of differentiation 1; EID-1MGC138883; EP300 interacting inhibitor of differentiation 1; IRO45620; NB4 apoptosis related protein; Rb- and p300-binding protein EID-1; RBP21; retinoblastoma protein-associated protein
Molecular Weight
Mass (kDA):
20.876 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q21.1 |
| Sequence: | 15; NC_000015.10 (48878134..48880173) |
Tissue Specificity
Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
Subcellular Localizations
Nucleus. Cytoplasm. May shuttle between nucleus and cytoplasm.
Diseases
- Malignant Neoplasms
- Retinoblastoma
- Neoplasms
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Malignant Paraganglionic Neoplasm
- Growth Arrest
- Malignant Neoplasm Of Lung
- Carcinogenesis
- Cell Transformation, Neoplastic
- Mucinous Adenocarcinoma
- Obesity
- Papillomavirus Infections
Interacting Proteins
- NDN
- Ndn
Pathways
- Cell Cycle
- Cell Cycle Arrest
- Localization
- Cell Proliferation
- G1 Phase
- Cell Death
- Pathogenesis
- Histone Acetylation
- Cell Growth
- Rna Interference
- Cell Cycle Checkpoint
- Muscle Cell Differentiation
- Gene Silencing
PTMs
- Acetylation
- Phosphorylation
Research Areas
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EID1
bosterbio.com/bosterbio-gene-info-cards/EID1
References
PMID: 11073990 by MacLellan W.R., et al. A novel Rb- and p300-binding protein inhibits transactivation by MyoD.
PMID: 11223246 by Wen H., et al. Identification and characterization of a novel human cDNA encoding a 21 kDa pRb-associated protein.