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EHMT2 Antibodies
AND EHMT2 ELISA kits, EHMT2 Proteins
Many biological assays use antibodies to detect EHMT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with EHMT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop EHMT2 antibodies...
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EHMT2 Infographic by Boster Bio
All EHMT2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01055-2
100 μg/vial
Cat # A01055-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M01055-1
100 μl/vial
Cat # M01055-1
100 μl/vial
EHMT2 Overview
Facts about Histone-lysine N-methyltransferase EHMT2.
Histone-lysine N-methyltransferase EHMT2 (EHMT2)
Histone methyltransferase that specifically mono- and dimethylates'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones.
Also mediates monomethylation of'Lys-56' of histone H3 (H3K56me1) at G1 phase, leading to encourage interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me).
Gene Information
| Human | |
|---|---|
| Gene Name: | EHMT2 |
| Uniprot: | Q96KQ7 |
| Entrez: | 10919 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
ankyrin repeat-containing protein; BAT8; C6orf30; chromosome 6 open reading frame 30; DKFZp686H08213; EC 2.1.1.-; EC 2.1.1.43; EHMT2; euchromatic histone-lysine N-methyltransferase 2HLA-B-associated transcript 8; FLJ35547; G9A histone methyltransferase; G9a; G9AEm:AF134726.3; H3-K9-HMTase 3; Histone H3-K9 methyltransferase 3; histone-lysine N-methyltransferase, H3 lysine-9 specific 3; HLA-B associated transcript 8; KMT1CNG36/G9a; Lysine N-methyltransferase 1C; NG36; Protein G9a
Molecular Weight
Mass (kDA):
132.37 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6p21.33 |
| Sequence: | 6; NC_000006.12 (31879759..31897698, complement) |
Tissue Specificity
Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow.
Subcellular Localizations
Nucleus. Chromosome. Associates with euchromatic regions. Does not associate with heterochromatin.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Leukemia
- Inflammation
- Neoplasm Metastasis
- Neoplasm Invasiveness
- Adenocarcinoma
- Malignant Neoplasm Of Lung
- Cell Transformation, Neoplastic
- Hypoxia
Interacting Proteins
- CDC73
- DNMT3B
- GATA3
- GFI1
- Gfi1
- HDAC1
- KAT2B
- KLF12
- MTA1
- MTA2
Pathways
- Methylation
- Dna Methylation
- Histone Methylation
- Regulation Of Gene Expression
- Demethylation
- Histone Modification
- Pathogenesis
- Gene Silencing
- Cell Migration
- Embryo Development
- Cell Differentiation
- Histone Acetylation
- Chromatin Remodeling
PTMs
- Methylation
- Acetylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EHMT2
bosterbio.com/bosterbio-gene-info-cards/EHMT2
References
PMID: 11707778 by Brown S.E., et al. Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions.
PMID: 8457211 by Milner C.M., et al. The G9a gene in the human major histocompatibility complex encodes a novel protein containing ankyrin-like repeats.