Polycomb protein EED Antibodies

Polycomb protein EED (EED)

Polycomb group (PcG) protein. Part of the PRC2/EED- EZH2 complex, which methylates'Lys-9' and'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.

Additionally admits'Lys-26' trimethylated histone H1 with the consequence of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3'Lys-27', whereas H3'Lys-27' recognition has the opposite effect, enabling the propagation of the repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems.

Gene Information

Human
Gene Name:	EED
Uniprot:	O75530
Entrez:	8726

Family

Belongs to:
WD repeat ESC family

Alternative Names

EED; embryonic ectoderm development; HEED; polycomb protein EED; WAIT1 ; WAIT1; WAIT-1; WD protein associating with integrin cytoplasmic tails 1

Molecular Weight

Mass (kDA):
50.198 kDA

Genomic Context

Human
Location:	11q14.2
Sequence:	11; NC_000011.10 (86244384..86285420)

Tissue Specificity

Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.

Subcellular Localizations

Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.

Diseases

• Malignant Neoplasms
• Neoplasms
• Immunologic Deficiency Syndromes
• Erythema
• Cerebrovascular Accident
• Leukemia
• Diabetes Mellitus
• Neoplasm Metastasis
• Prostatic Neoplasms
• Hiv Infections
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Prostate

• Heart Failure
• Lymphoma
• Vasculitis
• Pain
• Vasculitis, Leukocytoclastic, Cutaneous
• Ulcer
• Leukemia, Myelocytic, Acute

Interacting Proteins

• ASXL1
• CCT3
• DDB1
• DNMT1
• DNMT3A

• DNMT3B
• EZH2
• RACK1
• SMPD3
• Smpd3

• SUZ12

Pathways

• Methylation
• Ectoderm Development
• Gene Silencing
• Histone Methylation
• Gastrulation
• Histone Modification
• Cell Cycle
• Cell Differentiation
• Cell Proliferation
• Dna Methylation
• Localization
• Fertilization
• Rna Interference

• Histone Deacetylation
• Cell Growth
• Histone Acetylation
• Chromatin Remodeling
• Dna Replication
• Stem Cell Differentiation
• Wound Healing

PTMs

• Methylation
• Acetylation
• Cleavage
• Ubiquitination
• Phosphorylation

• Deacetylation
• Demethylation
• Glycosylation
• Oxidation
• Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EED

Boster Bio - Best Uses Of The EED Marker

Boster Bio's optimization guide contains a wealth of information. This guide will teach you everything you need to optimize your research, from how to select the best controls to how optimize your experiments. Nearly every researcher encounters problems during an experiment. However, by choosing the right controls, you can eliminate many of the possible sources of problems. The guide also offers helpful guidance on how troubleshoot STC1 Marking.

Boster Bio's ILP marker

Boster Bio has developed an IL6 marker proprietary to treat erectile disorder, or EED. The IL6 molecule can be described as a pleiotropic soluble mediation that modulates inflammation, immune reaction, and hematopoiesis. The molecules were given the names HSF, BSF-2, or HGF due to their biological activities. BSF-2 proteins induce the differentiation of activated B-cells. HSF promotes the growth and differentiation of plasma cells. HGF has antiviral properties.

Boster Bio's IL6 marker was tested using the IL-6 ELISA. It has been a great success in clinical trials. For patients with PR values of five, 10, and 15, the PPV (positive predictive value) of IL-6 reached 100%. For PR values greater than 5, 10, or 15, the NPV values were 98.7% and 95.8%, respectively. The IL-6 ELISA test is suitable for screening and treating patients with erectile dysfunction.

Boster Bio's Stanniocalcin-1 Antibody

Boster Bio's Stanniocalcim-1 Antibody is part Picoband(tm), which includes primary antibodies. The antibody reacts well with Human. It has been validated by Western blotting, immunohistochemistry, and ELISA. Boster has the largest collection of Chinese antibodies. The antibody is a high-affinity protein that can be stored at -20 degrees Celsius for one year or at 4 degrees Celsius for one month. It is made from recombinant Human Protein (Recombinant Human Protein) and Trehalose. The antibody comes with a blocking propeptide. It can be purchased for a fee that is based on the immunogen length.