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Polycomb protein EED Antibodies
AND EED ELISA kits, Polycomb protein EED Proteins
Many biological assays use antibodies to detect Polycomb protein EED, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polycomb protein EED in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polycomb protein EED antibodies...
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EED Infographic by Boster Bio
All EED Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01345-2
100 μg/vial
Cat # A01345-2
100 μg/vial
EED Overview
Facts about Polycomb protein EED.
Polycomb protein EED (EED)
Polycomb group (PcG) protein. Part of the PRC2/EED- EZH2 complex, which methylates'Lys-9' and'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene.
Additionally admits'Lys-26' trimethylated histone H1 with the consequence of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3'Lys-27', whereas H3'Lys-27' recognition has the opposite effect, enabling the propagation of the repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems.
Gene Information
| Human | |
|---|---|
| Gene Name: | EED |
| Uniprot: | O75530 |
| Entrez: | 8726 |
Family
| Belongs to: |
|---|
| WD repeat ESC family |
Alternative Names
EED; embryonic ectoderm development; HEED; polycomb protein EED; WAIT1 ; WAIT1; WAIT-1; WD protein associating with integrin cytoplasmic tails 1
Molecular Weight
Mass (kDA):
50.198 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q14.2 |
| Sequence: | 11; NC_000011.10 (86244384..86285420) |
Tissue Specificity
Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
Subcellular Localizations
Nucleus. Chromosome. Transiently colocalizes with XIST at inactive X chromosomes.
Diseases
- Malignant Neoplasms
- Neoplasms
- Immunologic Deficiency Syndromes
- Erythema
- Cerebrovascular Accident
- Leukemia
- Diabetes Mellitus
- Neoplasm Metastasis
- Prostatic Neoplasms
- Hiv Infections
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Prostate
Interacting Proteins
- ASXL1
- CCT3
- DDB1
- DNMT1
- DNMT3A
- DNMT3B
- EZH2
- RACK1
- SMPD3
- Smpd3
Pathways
- Methylation
- Ectoderm Development
- Gene Silencing
- Histone Methylation
- Gastrulation
- Histone Modification
- Cell Cycle
- Cell Differentiation
- Cell Proliferation
- Dna Methylation
- Localization
- Fertilization
- Rna Interference
PTMs
- Methylation
- Acetylation
- Cleavage
- Ubiquitination
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/EED
bosterbio.com/bosterbio-gene-info-cards/EED
References
PMID: 9806832 by Schumacher A., et al. The murine Polycomb-group gene eed and its human orthologue: functional implications of evolutionary conservation.
PMID: 9584199 by Sewalt R.G.A.B., et al. Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.