This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Endothelial differentiation-related factor 1.
Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism.
Human | |
---|---|
Gene Name: | EDF1 |
Uniprot: | O60869 |
Entrez: | 8721 |
Belongs to: |
---|
No superfamily |
EDF-1Multiprotein-bridging factor 1; endothelial differentiation-related factor 1; MBF1; MGC9058; multiprotein bridging factor 1; multiprotein bridging factor-1
Mass (kDA):
16.369 kDA
Human | |
---|---|
Location: | 9q34.3 |
Sequence: | 9; NC_000009.12 (136862119..136866336, complement) |
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
Cytoplasm. Nucleus. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
PMID: 9813014 by Dragoni I., et al. EDF-1, a novel gene product down-regulated in human endothelial cell differentiation.
PMID: 10567391 by Kabe Y., et al. The role of human MBF1 as a transcriptional coactivator.