ECD Antibodies

AND ECD ELISA kits, ECD Proteins

Many biological assays use antibodies to detect ECD, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ECD in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ECD antibodies...

We validate the specificity of these antibodies to ECD by testing them on tissues known to express ECD positively and negatively. Browse below to find the ECD antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ECD Infographic by Boster Bio

All ECD Products

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Product

Figures

Specificity

Applications

Price

Anti-SGT1/ECD Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, WB

$370
Cat # A00567-1
100 μg/vial

Anti-SGT1/ECD Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00567-2
100 μg/vial

SGT1 (ECD) (NM_007265) Human Over-expression Lysate

Human

$628
Cat # LS011319
100 µg

ECD Overview

Facts about Protein ecdysoneless homolog.

ECD 3D structure. Source: alphafold

Protein ecdysoneless homolog (ECD)

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345).

May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300.

Gene Information

Human
Gene Name:	ECD
Uniprot:	O95905
Entrez:	11319

Family

Belongs to:

ECD family

Alternative Names

ecdysoneless homolog (Drosophila); GCR2; HSGT1; Protein ecdysoneless homolog; protein SGT1; SGT1; Suppressor of GCR2; suppressor of S. cerevisiae gcr2; X

Molecular Weight

Mass (kDA):
72.758 kDA

Genomic Context


Human

Location:	10q22.2
Sequence:	10; NC_000010.11 (73133668..73168095, complement)

Tissue Specificity

Highly expressed in muscle and heart. Over- expressed in pancreatic and breast cancers.

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly is located in the cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Corneal Diseases
Malignant Neoplasm Of Breast
Epilepsy
Mammary Neoplasms
Delayed Graft Function
Cerebrovascular Accident
Neoplasm Metastasis
Carcinoma
Ischemia
Cataract
Hypertensive Disease

Diabetes Mellitus
Graft Failure
Edema
Tissue Adhesions
Dystrophy
Alzheimer's Disease
Infarction

Interacting Proteins

PIH1D1
PRPF8
RUVBL1
TXNIP

Pathways

Localization
Glycosylation
Transport
Pathogenesis
Immune Response
Secretion
Glomerular Filtration
Excretion
Aging
Cell Adhesion
Cell Proliferation
Proteolysis
Cell Growth

Cell Cycle
Fertilization
Regeneration
Angiogenesis
Protein Folding
Cell Death
Translation

PTMs

Cleavage
Phosphorylation
Glycosylation
Oxidation
Reduction
Nitration
Hydroxylation
Acetylation
Methylation
Bromination

Deamidation
Acylation
Deglycosylation
Carboxylation
Amidation
Dephosphorylation
Iodination
Myristoylation
Nitrosylation
Deamination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ECD

References

PMID: 9928932 by Sato T., et al. A human gene, hSGT1, can substitute for GCR2, which encodes a general regulatory factor of glycolytic gene expression in Saccharomyces cerevisiae.

PMID: 16849563 by Zhang Y., et al. The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function.