Dual oxidase 2 Antibodies

AND DUOX2 ELISA kits, Dual oxidase 2 Proteins

Many biological assays use antibodies to detect Dual oxidase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Dual oxidase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Dual oxidase 2 antibodies...

We validate the specificity of these antibodies to Dual oxidase 2 by testing them on tissues known to express DUOX2 positively and negatively. Browse below to find the DUOX2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DUOX2 Infographic by Boster Bio

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Anti-Duox2 Antibody Picoband®

Mouse, Rat

ELISA, IHC, WB

$370
Cat # A02186
100 μg/vial

DUOX2 Overview

Facts about Dual oxidase 2.

DUOX2 3D structure. Source: alphafold

Dual oxidase 2 (DUOX2)

Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense in the surface of mucosa.

May have its own peroxidase activity through its N-terminal peroxidase-like domainname. .

Gene Information

Human
Gene Name:	DUOX2
Uniprot:	Q9NRD8
Entrez:	50506

Family

Belongs to:

No superfamily

Alternative Names

dual oxidase 2; dual oxidase-like domains 2; EC 1.11.1.-; EC 1.6.3.1; flavoprotein NADPH oxidase; Large NOX 2; LNOX2P138(TOX); Long NOX 2; NADH/NADPH thyroid oxidase p138-tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; nicotinamide adenine dinucleotide phosphate oxidase; NOXEF2; p138 thyroid oxidase; P138-TOX; THOX2TDH6; Thyroid oxidase 2

Molecular Weight

Mass (kDA):
175.364 kDA

Genomic Context


Human

Location:	15q21.1
Sequence:	15; NC_000015.10 (45092650..45114172, complement)

Tissue Specificity

Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum and testis.

Subcellular Localizations

Apical cell membrane; Multi-pass membrane protein. Cell junction. Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens, such as Escherichia coli.

Diseases

Hypothyroidism
Congenital Hypothyroidism
Goiter
Malignant Neoplasms
Neoplasms
Inflammation
Adenoma
Carcinoma
Thyroid Diseases
Lung Diseases
Thyroid Neoplasm
Carcinoma, Papillary
Intestinal Diseases

Infective Disorder
Inflammatory Bowel Diseases
Carcinogenesis
Colitis
Adenocarcinoma
Cystic Fibrosis
Congenital Goiter

Pathways

Pathogenesis
Localization
Transport
Fertilization
Translation
Wound Healing
Methylation
Immune Response
Inflammatory Response
Phagocytosis
Dna Methylation
Cell Death
Rna Interference

Secretion
Iodide Transport
Cell Migration
Programmed Cell Death
Proteolysis
Response To Virus
Regulation Of Gene Expression

PTMs

Phosphorylation
Glycosylation
Iodination
Methylation

Biotinylation
Reduction
Cleavage
Oxidation

Deglycosylation

Research Areas

Cell Biology
Lipid and Metabolism
Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DUOX2

References

PMID: 10806195 by De Deken X., et al. Cloning of two human thyroid cDNAs encoding new members of the NADPH oxidase family.

PMID: 11514595 by Edens W.A., et al. Tyrosine cross-linking of extracellular matrix is catalyzed by Duox, a multidomain oxidase/peroxidase with homology to the phagocyte oxidase subunit gp91phox.