DLC1 Antibodies

AND DLC1 ELISA kits, DLC1 Proteins

Many biological assays use antibodies to detect DLC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with DLC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop DLC1 antibodies...

We validate the specificity of these antibodies to DLC1 by testing them on tissues known to express DLC1 positively and negatively. Browse below to find the DLC1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DLC1 Infographic by Boster Bio

All DLC1 Products

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Product

Figures

Specificity

Applications

Price

Anti-RHG07 DLC1 Antibody

3 Q&As

Human, Mouse, Rat

ELISA, IF, IHC-P, ICC

$335
Cat # A30552
100ul

Anti-DLC1 Antibody

Mouse, Rat

$405
Cat # A02013
100ul

DLC1 (NM_182643) Human Over-expression Lysate

Human

$628
Cat # LS010395
100 µg

DLC1 Overview

Facts about Rho GTPase-activating protein 7.

DLC1 3D structure. Source: alphafold

Rho GTPase-activating protein 7 (DLC1)

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling.
This induces morphological changes and detachment through cytoskeletal reorganization, playing a crucial role in biological processes such as cell migration and proliferation.

Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.

Gene Information

Human
Gene Name:	DLC1
Uniprot:	Q96QB1
Entrez:	10395

Family

Belongs to:

No superfamily

Alternative Names

ARHGAP7 STARD12 deleted in liver cancer 1 variant 2; Deleted in liver cancer 1 protein; deleted in liver cancer 1; DLC-1; FLJ21120; HP protein; HP; KIAA1723; p122-RhoGAP; rho GTPase-activating protein 7; Rho-GTPase-activating protein 7; Rho-type GTPase-activating protein 7; StARD12; StAR-related lipid transfer (START) domain containing 12; StAR-related lipid transfer protein 12; START domain-containing protein 12

Molecular Weight

Mass (kDA):
170.591 kDA

Genomic Context


Human

Location:	8p22
Sequence:	8; NC_000008.11 (13083361..13604620, complement)

Tissue Specificity

Highest level of expression in the spleen, with rather lower levels in prostate, testis, ovary, small intestine and colon, but none in the thymus.

Subcellular Localizations

Cytoplasm. Cell junction, focal adhesion. Membrane; Peripheral membrane protein. Colocalizes with EF1A1 at actin-rich regions in the cell periphery.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Malignant Neoplasm Of Liver
Liver Carcinoma
Tissue Adhesions
Liver Neoplasms
Cell Transformation, Neoplastic
Malignant Neoplasm Of Breast
Carcinogenesis
Neoplasm Metastasis
Cell Invasion

Mammary Neoplasms
Malignant Neoplasm Of Lung
Malignant Neoplasm Of Prostate
Neoplasm Invasiveness
Lung Neoplasms
Hepatocarcinogenesis
Prostatic Neoplasms

Interacting Proteins

RASA1

Pathways

Methylation
Localization
Cell Migration
Cell Proliferation
Cell Growth
Pathogenesis
Dna Methylation
Cell Cycle
Cell Motility
Induction Of Apoptosis
Transport
Gene Silencing
Demethylation

Rna Interference
Cell Cycle Arrest
Angiogenesis
Oncogenesis
Chromosome Segregation
Macropinocytosis
Drug Resistance

PTMs

Methylation
Phosphorylation
Demethylation
Acetylation

Deacetylation
Dephosphorylation
Reduction
Cleavage

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DLC1

References

PMID: 9605766 by Yuan B.Z., et al. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.

PMID: 21217778 by Low J.S., et al. A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.