m7GpppX diphosphatase Antibodies

AND DCPS ELISA kits, m7GpppX diphosphatase Proteins

Many biological assays use antibodies to detect m7GpppX diphosphatase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with m7GpppX diphosphatase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop m7GpppX diphosphatase antibodies...

We validate the specificity of these antibodies to m7GpppX diphosphatase by testing them on tissues known to express DCPS positively and negatively. Browse below to find the DCPS antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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DCPS Infographic by Boster Bio

All DCPS Products

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Specificity

Applications

Price

DCPS (NM_014026) Human Recombinant Protein

$1062
Cat # PROTQ96C86
20 µg

Anti-DCPS Mouse Monoclonal Antibody [Clone ID: OTI4H8]

Human, Mouse, Rat

IHC, WB

$523
Cat # M02684
100 µl

DCPS (NM_014026) Human Over-expression Lysate

Human

$628
Cat # LS028960
100 µg

DCPS Overview

Facts about m7GpppX diphosphatase.

DCPS 3D structure. Source: alphafold

m7GpppX diphosphatase (DCPS)

Decapping scavenger enzyme that catalyzes the cleavage of a residual cap arrangement after the degradation of mRNAs from the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP).

Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficacy. Doesn't hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules more than 25 nucleotides.

Gene Information

Human
Gene Name:	DCPS
Uniprot:	Q96C86
Entrez:	28960

Family

Belongs to:

HIT family

Alternative Names

DCS1; DCS-1; decapping enzyme, scavenger; EC 3.-; heat shock-like protein 1; HINT5; HINT-5homolog of C. elegans 7meGMP-directed hydrolase dcs-1; Hint-related 7meGMP-directed hydrolase; Histidine triad protein member 5; HSL1; HSPC015; mRNA decapping enzyme; scavenger mRNA-decapping enzyme DcpS

Molecular Weight

Mass (kDA):
38.609 kDA

Genomic Context


Human

Location:	11q24.2
Sequence:	11; NC_000011.10 (126304060..126350005)

Tissue Specificity

Detected in liver, brain, kidney, testis and prostate.

Subcellular Localizations

Cytoplasm. Nucleus. Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.

Diseases

Pain
Malignant Neoplasms
Neoplasms
Acquired Immunodeficiency Syndrome
Classical Galactosemia
Malignant Neoplasm Of Breast
Varicosity
Ataxia
Syphilis, Congenital
Fracture

Self-destructive Behavior
Oculomotor Apraxia
Syphilis
Antiphospholipid Syndrome

Pathways

Translation
Localization
Cell Cycle Arrest
Cell Cycle
Glycosylation
Regulation Of Gene Expression
Rna Processing
Transport
Intracellular Transport
Cellular Homeostasis
Dna Repair

Proteolysis
Nuclear Export
Lipid Binding
Innervation
Regulation Of Mrna Stability
Nuclear Import

PTMs

Cleavage
Phosphorylation
Phosphorothioation

Methylation
Deglycosylation
Ubiquitination

Research Areas

Stem Cell Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/DCPS

References

PMID: 12198172 by Liu H., et al. The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases.

PMID: 12871939 by Kwasnicka D.A., et al. Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1.